Results 31 to 40 of about 7,398,089 (304)

Abnormalities of cerebral perfusion in multiple sclerosis [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2004
Measuring perfusion provides a potential indication of metabolic activity in brain tissue. Studies in multiple sclerosis (MS) have identified areas of decreased perfusion in grey matter (GM) and white matter (WM), but the pattern in clinical subgroups is unclear.This study investigated perfusion changes in differing MS clinical subgroups on or off beta-
Rashid, W., Parkes, L. M., Ingle, G. T., Chard, D. T., Toosy, A. T., Altmann, D. R., Symms, M. R., Tofts, P. S., Thompson, A. J., Miller, D. H.   +9 more
openaire   +3 more sources

Prognostic implications of abnormalities of chromosome 13 and the presence of multiple cytogenetic high-risk abnormalities in newly diagnosed multiple myeloma

Blood Cancer Journal, 2017
Fluorescence in situ hybridization evaluation is essential for initial risk stratification in multiple myeloma. While the presence of specific cytogenetic high-risk abnormalities (HRA) is known to confer a poor prognosis, less is known about the ...
M. Binder, S. Rajkumar, R. Ketterling, P. Greipp, A. Dispenzieri, M. Lacy, M. Gertz, F. Buadi, S. Hayman, Y. Hwa, S. Zeldenrust, J. Lust, S. Russell, N. Leung, P. Kapoor, R. Go, W. Gonsalves, R. Kyle, S. Kumar   +18 more
semanticscholar   +1 more source

Abnormal Tr1 differentiation in multiple sclerosis [PDF]

Journal of Neuroimmunology, 2007
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). In the recent years, accumulating evidence has supported an immunosuppressive role for regulatory T cells (Tregs). Most studies in the context of autoimmunity have focused on the defects of the CD4+CD25 high Tregs.
Astier, Anne, Hafler, David
openaire   +3 more sources

Absence of cytoglobin promotes multiple organ abnormalities in aged mice

Scientific Reports, 2016
Cytoglobin (Cygb) was identified in hepatic stellate cells (HSCs) and pericytes of all organs; however, the effects of Cygb on cellular functions remain unclear.
L. Thuy, Tuong Thi Van Thuy, Y. Matsumoto, H. Hai, Y. Ikura, K. Yoshizato, N. Kawada   +6 more
semanticscholar   +1 more source

Periventricular magnetisation transfer abnormalities in early multiple sclerosis

NeuroImage: Clinical, 2022
Objective: Recent studies suggested that CSF-mediated factors contribute to periventricular (PV) T2-hyperintense lesion formation in multiple sclerosis (MS) and this in turn correlates with cortical damage.
Lukas Pirpamer, Bálint Kincses, Zsigmond Tamás Kincses, Christian Kiss, Anna Damulina, Michael Khalil, Rudolf Stollberger, Reinhold Schmidt, Christian Enzinger, Stefan Ropele   +9 more
doaj  

Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis.

Brain : a journal of neurology, 2015
In multiple sclerosis, there is increasing evidence that demyelination, and neuronal damage occurs preferentially in cortical grey matter next to the outer surface of the brain.
Zheng Liu, M. Pardini, Ö. Yaldizli, V. Sethi, N. Muhlert, C. Wheeler-Kingshott, R. Samson, David H. Miller, D. Chard   +8 more
semanticscholar   +1 more source

A practical method for prenatal diagnosis of anal atresia by second trimester ultrasound screening - A retrospective study

Taiwanese Journal of Obstetrics & Gynecology, 2023
Objectives: The study aimed to demonstrate the performance of anal atresia ultrasound screening in the second trimester and to describe associated experiences in a primary care fetal medicine clinic. Materials and methods: We retrospectively analyzed the
Hsuan Ko, Yu-Ching Chou, Ksenia Olisova, Tung-Yao Chang   +3 more
doaj  

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Prognostic Impact of Cytogenetic Abnormalities in Multiple Myeloma

Medicine, 2016
The identification of specific cytogenetic abnormalities by interphase fluorescence in situ hybridization (i-FISH) has become a routine procedure for prognostic stratification of multiple myeloma (MM) patients.
Y. Jian, Xiaolei Chen, Huixing Zhou, Wan-Qiu Zhu, Nian Liu, C. Geng, Wenming Chen   +6 more
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source