Results 51 to 60 of about 1,180,087 (300)

Bandit Models of Human Behavior: Reward Processing in Mental Disorders

, 2017
Drawing an inspiration from behavioral studies of human decision making, we propose here a general parametric framework for multi-armed bandit problem, which extends the standard Thompson Sampling approach to incorporate reward processing biases ...
A Dezfouli, AD Redish, AM Taylor, D Bouneffouf, D Bouneffouf, DC Perry, LE Hess, M Luman, MJ Frank, P Auer, P Auer, P Auer, TL Lai, TU Hauser, W Thompson, WR Thompson, WW Seeley   +16 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Characterization of an Inherited Neurologic Syndrome in Toyger Cats with Forebrain Commissural Malformations, Ventriculomegaly and Interhemispheric Cysts. [PDF]

, 2016
BackgroundIn children, frequent congenital malformations with concomitant agenesis of the corpus callosum are diagnosed by neuroimaging in association with other cerebral malformations, including interhemispheric cysts and ventriculomegaly.
Creighton, EK, Keating, MK, Lyons, LA, Sisó, S, Sturges, BK, Wisner, ER   +5 more
core  

Cerebral venous hemodynamic abnormalities in episodic and chronic migraine [PDF]

, 2016
Alterations of cerebral venous drainage have been demonstrated in chronic migraine (CM), suggesting that cerebral venous hemodynamic abnormalities (CVHAs) play a role in this condition.
Di Biase, A, DI PIERO, Vittorio, Passarelli, F, PETOLICCHIO, BARBARA, Tatulli, D, TOSCANO, MASSIMILIANO, Vicenzini, E, VIGANO', ALESSANDRO   +7 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Familial Cancers of Head and Neck Region [PDF]

Journal of Clinical and Diagnostic Research, 2017
Cancers that occur in families more often than would be expected by chance are termed as familial cancers. They occur due to an inherited genetic mutation and account for 5%-10% of all cancers.
Reshma Venugopal, Radhika Manoj Bavle, Paremala Konda, Sudhakara Muniswamappa, Soumya Makarla   +4 more
doaj   +1 more source

Fontan Circulation Associated Organ Abnormalities Beyond the Heart, Lungs, Liver, and Gut: A Systematic Review

Frontiers in Cardiovascular Medicine, 2022
IntroductionPatients with a Fontan circulation are at risk for sequelae of Fontan physiology during follow-up. Fontan physiology affects all organ systems and an overview of end-organ damage is needed.MethodsWe performed a systematic review of ...
Evi Ritmeester, Veerle A. Veger, Jelle P. G. van der Ven, Jelle P. G. van der Ven, Gabrielle M. J. W. van Tussenbroek, Carine I. van Capelle, Floris E. A. Udink ten Cate, Willem A. Helbing, Willem A. Helbing   +8 more
doaj   +1 more source

Born too early and too small: higher order cognitive function and brain at risk at ages 8–16 [PDF]

, 2019
Prematurity presents a risk for higher order cognitive functions. Some of these deficits manifest later in development, when these functions are expected to mature. However, the causes and consequences of prematurity are still unclear.
Clark, Chris A., Clayden, Jonathan D., Córcoles Parada, Marta, Giménez Mateo, Rocío, López, Leidy, Mansilla, Francisco, Martínez, Andrés, Muñoz López, Mónica, Onsurbe, Ignacio, Pérez Hernández, Elena, San Román, Paloma, Serrano del Pueblo, Víctor, Ubero Martínez, Mar   +12 more
core   +5 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy

Frontiers in Aging Neuroscience, 2020
Purpose: This study aimed to identify consistent gray matter volume (GMV) changes in the two subtypes of multiple system atrophy (MSA), including parkinsonism subtype (MSA-P), and cerebellar subtype (MSA-C), by conducting a voxel-wise meta-analysis of ...
Junyu Lin, Xinran Xu, Yanbing Hou, Jing Yang, Huifang Shang   +4 more
doaj   +1 more source