Abstract Background The contribution of tumor type, multimodal treatment, and other patient‐related factors upon long‐term cognitive sequelae in infant brain tumor survivors remains undefined. We add our retrospective analysis of neuropsychological and quality of survival (QoS) outcome data of survivors of atypical teratoid/rhabdoid tumors (ATRT) and ...
Thomas Traunwieser +27 more
wiley +1 more source
Arterial Spin-Labeling Perfusion Metrics in Pediatric Posterior Fossa Tumor Surgery [PDF]
BACKGROUND AND PURPOSE: Pediatric posterior fossa tumors often present with hydrocephalus; postoperatively, up to 25% of patients develop cerebellar mutism syndrome. Arterial spin-labeling is a noninvasive means of quantifying CBF and bolus arrival time.
Aquilina, K +7 more
core
Pre‐operative scan reveals epidural tissue from D7 to D11, which compresses and dislocates the dural sac. Post‐ operative scan shows surgical removal of the neoplastic intacanal component, with complete resolution of the mass effect. Key Clinical Message Spinal cord compression from non‐Hodgkin lymphoma (NHL) should be considered as a potential ...
Daniele Zama +7 more
wiley +1 more source
International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors
Abstract Background Sinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represent a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and ...
Edward C. Kuan +158 more
wiley +1 more source
Diffusion and Perfusion MRI in Paediatric Posterior Fossa Tumours [PDF]
Brain tumours in children frequently occur in the posterior fossa. Most undergo surgical resection, after which up to 25% develop cerebellar mutism syndrome (CMS), characterised by mutism, emotional lability and cerebellar motor signs; these typically ...
Toescu, Sebastian
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The mitochondrial translocator protein in human gliomas
The translocator protein (TSPO) is an 18 kDa molecule spanning the outer mitochondrial membrane. Structural predictions, reported physical interactions and experimental data from diverse models suggest that TSPO is involved in apoptosis, proliferation ...
Janczar, Karolina, Janczar, Karolina
core +1 more source
Identification of the cellular origin and 'stemness' phenotype of Malignant Rhabdoid Tumours (MRT) may represent a new therapeutic approach in paediatric oncology [PDF]
PhD ThesisIntroduction: Malignant Rhabdoid Tumours (MRT) are especially lethal cancers that predominantly occur in infants and young children. MRT are caused by biallelic inactivation of a single gene; SMARCB1 which is a component of SWI/SNF chromatin
Ramli, Ras Azira Binti
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Next-generation sequencing identifies mechanisms of tumourigenesis caused by loss of SMARCB1 in Malignant Rhabdoid Tumours [PDF]
PhD ThesisIntroduction: Malignant Rhabdoid Tumours (MRT) are unique malignancies caused by biallelic inactivation of a single gene (SMARCB1). SMARCB1 encodes for a protein that is part of the SWI/SNF chromatin remodelling complex, responsible for the ...
Finetti, Martina Anna
core
Relapsed and refractory malignant rhabdoid tumors – Evaluation of new therapeutic approaches [PDF]
Relapse or progression of malignant rhabdoid tumors (MRT) is a frequent event, but our knowledge on this topic is insufficient. There is no standard algorithm for salvage therapy and clinical trial access is limited for this young patient population. The
Steinbügl, Mona Juliane
core
Quantitative Assessment of Whole-Body Tumor Burden in Adult Patients with Neurofibromatosis [PDF]
Patients with neurofibromatosis 1 (NF1), NF2, and schwannomatosis are at risk for multiple nerve sheath tumors and premature mortality. Traditional magnetic resonance imaging (MRI) has limited ability to assess disease burden accurately.
Alona Muzikansky +53 more
core +3 more sources

