Cancer Predisposition Genes in Adolescents and Young Adults (AYAs): a Review Paper from the Italian AYA Working Group [PDF]
Purpose of Review: The present narrative systematic review summarizes current knowledge on germline gene mutations predisposing to solid tumors in adolescents and young adults (AYAs).
Banna G. L. +7 more
core +4 more sources
A Personalised Vaccination Program Based on Immune Reconstitution in Paediatric Cancer Survivors
ABSTRACT Aims Paediatric cancer survivors often experience treatment‐induced immunosuppression, requiring post‐treatment revaccination. However, immune recovery timelines vary, and current revaccination guidelines, largely based on data of varied quality derived from studies on acute‐lymphoblastic‐leukaemia (ALL), may not be applicable across all ...
Menucha Jurkowicz +17 more
wiley +1 more source
Median alveolar cleft and palatal mass without a median upper cleft lip [PDF]
Median cleft is rare among facial clefts, including bilateral and unilateral clefts. Median upper cleft lip and median alveolar cleft correspond to Type 14 and Type 0, respectively, in Tessier's classification system.
Kawai, Katsuya +4 more
core +1 more source
Estimating brain volume loss after radiation therapy in children treated for posterior fossa tumors (Corpus callosum and whole brain volume changes following radiotherapy in children). [PDF]
Background More than half of pediatric tumors of central nervous system (CNS) primarily originate in the posterior fossa and are conventionally treated with radiation therapy (RT).Objectives The objective of this study was to establish whether corpus ...
Clark, C +7 more
core +2 more sources
Consensus recommendations on counselling in Phelan-McDermid syndrome, with special attention to recurrence risk and to ring chromosome 22 [PDF]
This paper focuses on genetic counselling in Phelan-McDermid syndrome (PMS), a rare neurodevelopmental disorder caused by a deletion 22q13.3 or a pathogenic variant in SHANK3.
Anderlid, B.M. +10 more
core +2 more sources
CAR‐T Cells: Current Status, Challenges, and Future Prospects
This graphical abstract outlines the current status, challenges, and future prospects of CAR‐T cells. The biological basis of CAR‐T cell therapy is the elegant redirection of adaptive immunity. Its initial successes have exposed a landscape of multifaceted challenges.
Aya Sedky Adly +6 more
wiley +1 more source
ABSTRACT Background Posterior fossa tumours (PFT), among the most common childhood brain tumours, place children at risk of speech, language, and communication difficulties, often described in relation to cerebellar mutism syndrome (CMS) but also seen in children without mutism.
K. Persson +7 more
wiley +1 more source
Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin +10 more
wiley +1 more source
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +3 more sources
The effectiveness and safety of proton beam radiation therapy in children and young adults with Central Nervous System (CNS) tumours:a systematic review [PDF]
BACKGROUND: Central nervous system (CNS) tumours account for around 25% of childhood neoplasms. With multi-modal therapy, 5-year survival is at around 75% in the UK. Conventional photon radiotherapy has made significant contributions to survival, but can
Dandapani, Madhumita +10 more
core +2 more sources

