Results 61 to 70 of about 863,191 (328)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Abnormality in the Theory of Necessary Optimality Conditions
Известия Иркутского государственного университета: Серия "Математика", 2017 The problems of existence, non-uniqueness, abnormality of solutions arising from the using of necessary optimality conditions are discussed in terms of the extension principle and sufficient optimality conditions. Simple examples are used.
V.I. Gurman, M.M. Khrustalev
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Severe acute respiratory distress syndrome caused by Otsujito
Acute Medicine & Surgery, 2023 Background Kampo prescriptions can cause drug‐induced lung injury (DLI) and acute respiratory distress syndrome (ARDS). However, severe respiratory failure induced by Otsujito (OJT) is extremely rare. High‐dose steroid pulse therapy is generally given to
Nobuhisa Hirasawa +4 more
doaj +1 more source
Concomitant t(8;21) and trisomy 4 in a patient with Acute Myeloid Leukemia (AML) [PDF]
, 2010 The t(8;21)(q22;q22) is a frequently occurring aberration in acute myeloid leukemia (AML) (18-20%) and usually correlate with French-America-British (FAB) M2 subtype.
Chang KM, +4 more
core
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
The Painful Long Head of the Biceps Brachii: Nonoperative Treatment Approaches [PDF]
, 2016 Pain associated with the long head of the biceps (LHB) brachii seems to be increasingly recognized in the past 4 to 5 years. The LHB has long been considered a troublesome pain generator in the shoulder.
Hooks, Todd R., Wilk, Kevin E.
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Review of Abnormal Self-Knowledge in Major Depressive Disorder
Frontiers in Psychiatry, 2019 Background: Major depressive disorder (MDD) is an affective disorder that is harmful to both physical and mental health. Abnormal self-knowledge, which refers to abnormal judgments about oneself, is a core symptom of depression.
Yixue Lou +9 more
doaj +1 more source
A Multi-Dimensional approach towards Intrusion Detection System
, 2012 In this paper, we suggest a multi-dimensional approach towards intrusion detection. Network and system usage parameters like source and destination IP addresses; source and destination ports; incoming and outgoing network traffic data rate and number of ...
Sanyal, Sugata +1 more
core +3 more sources