Results 1 to 10 of about 723,767 (301)
Foods, 2021 (1) Background: The volume-viscosity swallow test (V-VST) is a clinical tool for screening and diagnosis of oropharyngeal dysphagia (OD). Our aims were to examine the clinical utility of the V-VST against videofluoroscopy (VFS) or fiberoptic endoscopic ...
Stephanie A. Riera +7 more
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Objective assessment of eye alignment and disparity-driven vergence in Parkinson’s disease
Frontiers in Aging Neuroscience, 2023 BackgroundSelf-reported diplopia is described in up to one-third of Parkinson’s disease (PD) patients.ObjectiveThe purpose of our study was to expand our understanding of the mechanistic underpinnings of diplopia in PD. We hypothesize that the time-based
Palak Gupta +12 more
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Effects of in vitro lipid overload on LX-2 hepatic stellate cells
Annals of Hepatology, 2022 Introduction and Objectives: Studying lipid overload repercussions on hepatic stellate cells (HSC) is of great importance due to their role in fibrosis during NAFLD. Steatogenic cell culture of HSC is intended to elucidate pathogenic mechanisms in NAFLD.
A Campos-Espinosa +2 more
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Frontiers in Physiology, 2022 Myosin VI (MVI) is a unique unconventional myosin ubiquitously expressed in metazoans. Its diverse cellular functions are mediated by interactions with a number of binding partners present in multi-protein complexes.
Lilya Lehka +5 more
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A new interpretation and quantitative method for diplopia test: 304 cases of ocular motor nerve palsy for clinical test and verify [PDF]
International Journal of Ophthalmology, 2017 We introduce a new interpretation and quantitative method for computerized diplopia test. By comparing this new method to the Hess screen test, we validate its applicability among 304 patients with ocular motor nerve palsy.
Ling-Yun Zhou +5 more
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Assessment of cellular proliferation, death and senescence in a model of steatosis in vitro
Annals of Hepatology, 2022 Introduction and objectives: Hepatocyte cell culture in steatogenic medium is a useful, reproducible tool. During NAFLD, cells undergo processes in response to the steatogenic input. Here we aimed to study cellular proliferation, death, and senescence in
A Campos-Espinosa +2 more
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How myosin VI traps its off-state, is activated and dimerizes
Nature Communications, 2023 Myosin VI (Myo6) is the only minus-end directed nanomotor on actin, allowing it to uniquely contribute to numerous cellular functions. As for other nanomotors, the proper functioning of Myo6 relies on precise spatiotemporal control of motor activity via ...
Louise Canon +22 more
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A Unifying Model-Based Hypothesis for the Diverse Waveforms of Infantile Nystagmus Syndrome
Journal of Eye Movement Research, 2011 We expanded the original behavioral Ocular Motor System (OMS) model for Infantile Nystagmus Syndrome (INS) by incorporating common types of jerk waveforms within a unifying mechanism.
Zhong I. Wang, Louis F. Dell'Osso
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Myosin 7 and its adaptors link cadherins to actin
Nature Communications, 2017 Cadherin is essential for mechanotransduction and myosin-adaptor-harmonin complexes anchor it to actin. Here the authors present the structures of myosin 7 MF2 domains bound to the harmonin PDZ3c domain and give insights into myosin-adaptor-harmonin ...
I-Mei Yu +8 more
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Nature Communications, 2017 Omecamtiv mecarbil (OM) is a cardiac myosin activator that is currently in clinical trials for heart failure treatment. Here, the authors give insights into its mode of action and present the crystal structure of OM bound to bovine cardiac myosin, which ...
Vicente J. Planelles-Herrero +4 more
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