Results 31 to 40 of about 539,525 (316)

A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity [PDF]

, 2010
Toxoplasma gondii is an obligate intracellular parasite that enters cells by a process of active penetration. Host cell penetration and parasite motility are driven by a myosin motor complex consisting of four known proteins: TgMyoA, an unconventional ...
Carey, Kimberly L., Federica Catti, David M Warshaw, Nicholas J Westwood, Catti, Federica, Gary E Ward, Jacqueline M Leung, Kimberly L Carey, Leung, Jacqueline M., Warshaw, David M., Ballif, Bryan A., Heaslip, Aoife T., Bryan A Ballif, Westwood, Nicholas J., Ward, Gary E., Aoife T Heaslip, Catti Federica, Leung Jacqueline M., Carey Kimberly L., Warshaw David M., Ballif Bryan A., Westwood Nicholas J., Ward Gary E., Heaslip Aoife T., Westwood, Nicholas J.; id_orcid   +24 more
core   +2 more sources

Skeletal muscle as a source of IGFBP-2 in a murine model of metabolic dysfunction associated with steatotic liver disease.

Annals of Hepatology
Introduction and Objectives: Insulin-like Growth Factor Binding Protein (IGFBP)-2 is lower in serum during obesity and metabolic dysfunction. We have previously shown that the decrease in serum IGFBP-2 follows a diminished expression in liver and heart ...
Miriam G. Bautista-Ubaldo, Bryan M. Ata-Calixto, Diana Paola Osnaya-Burgos, Ignacio González-Sánchez, Gabriela Gutiérrez-Reyes, Carolina Guzmán   +5 more
doaj   +1 more source

Jackhammer Esophagus: From Manometric Diagnosis to Clinical Presentation

Canadian Journal of Gastroenterology and Hepatology, 2019
Background. Jackhammer esophagus is a hypercontractile esophageal disorder recently brought to light with the advent of high resolution manometry (HRM).
Marianne Clément, Wen Jing Zhu, Elissaveta Neshkova, Mickael Bouin   +3 more
doaj   +1 more source

Fixation eye movement abnormalities and stereopsis recovery following strabismus repair

Scientific Reports, 2021
We evaluated the effects of strabismus repair on fixational eye movements (FEMs) and stereopsis recovery in patients with fusion maldevelopment nystagmus (FMN) and patients without nystagmus.
Talora L. Martin, Jordan Murray, Kiran Garg, Charles Gallagher, Aasef G. Shaikh, Fatema F. Ghasia   +5 more
doaj   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility

, 2020
Paraspeckle protein 1 (PSPC1) overexpression in cancers is known to be the pro-metastatic switch of tumor progression associated with poor prognosis of cancer patients.
Yaw-Dong Lang, Yuh-Shan Jou, De-Leung Gu, Hsin-Wei Jen   +3 more
core   +1 more source

A European Approach to Irritable Bowel Syndrome Management

Canadian Journal of Gastroenterology, 1999
Irritable bowel syndrome (IBS) is characterized by a number of clinical features and probably comprises a cluster of different conditions. The most frequent symptom reported by IBS patients is abdominal pain, although for a number of patients, bowel ...
Michel Delvaux, Jacques Frexinos
doaj   +1 more source

Transmembrane Protein 100 Inhibits the Progression of Colorectal Cancer by Promoting the Ubiquitin/Proteasome Degradation of HIF-1α

Frontiers in Oncology, 2022
Transmembrane protein 100 (TMEM100) is involved in embryonic cardiovascular system development. However, the biological role of TMEM100 in human cancers, particularly colorectal cancer (CRC), is unclear.
Ying Zheng, Yitong Zhao, Jiong Jiang, Baicang Zou, Lei Dong   +4 more
doaj   +1 more source

Parents of Youth With Cancer Report on Their Psychosocial Care: iSTEPPP Survey Finds Alignment and Gaps With Standards

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families guide the provision of comprehensive psychosocial care. Parallel to research characterizing implementation of the Standards from the perspective of providers, this study examines implementation of the Standards from the perspective of parents of youth ...
Emily M. Pariseau, Kimberly Buff, Michele A. Scialla, Kimberly S. Canter, Lori Wiener, Victoria Sardi‐Brown, Julia B. Tager, Kamyar Arasteh, Anne E. Kazak   +8 more
wiley   +1 more source

Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion [PDF]

, 2014
This work was supported by US Public Health Service grant AI054961 (GEW/NJW), a University Research Fellowship from the Royal Society (NJW) and funding for the mass spectrometry analysis was provided by the Vermont Genetics Network/NIH Grant 8P20GM103449
Pathak, R.B., Bryan A. Ballif (238963), Nicholas J Westwood, Westwood, N.J., Gary E Ward, Leung, J.M., Jacqueline M Leung, Poupart, S., Ward, G.E., Nicholas J. Westwood (254891), Séverine Poupart (571871), Gary E. Ward (208054), Ballif, B.A., Séverine Poupart, Tran, F., Aoife T. Heaslip (207534), Bryan A Ballif, Fanny Tran, Aoife T Heaslip, Fanny Tran (571869), Jacqueline M. Leung (120235), Heaslip, A.T., Ravindra B Pathak, Ravindra B. Pathak (571870), Ballif Bryan A., Westwood Nicholas J., Tran Fanny, Pathak Ravindra B., Leung Jacqueline M., Poupart Séverine, Ward Gary E., Heaslip Aoife T., Westwood, N.J.; id_orcid   +32 more
core   +2 more sources