Results 71 to 80 of about 549,661 (323)

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee, Graeme S. V. McDowell, Darryl C. De Vivo, Daniel Friedman, Samuel F. Berkovic, Maria Spanou, Argirios Dinopoulos, Katheryn Grand, Pedro A. Sanchez‐Lara, Michelle Allen‐Sharpley, Jodi Warman‐Chardon, Alexander Solyom, Thierry Levade, Edward H. Schuchman, Steffany A. L. Bennett, David A. Dyment, Toni S. Pearson   +16 more
wiley   +1 more source

Association of Vitamin D deficiency with cardiovascular disease among Saudi patients in Saudi Arabia

International Journal of Preventive Medicine, 2020
Background: Vitamin D deficiency has a far-reaching impact on several metabolic functions including cardiovascular health. This study aimed to test the association of serum 25 [OH]-vitamin D3 levels among cardiovascular disease (i.e., hypertension and ...
Salem Jabbar Hamdan Alghamdi, Eltigani O M. Omer, Mubashir Zafar, Hatem Khader Ibrahim Herzallah   +3 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1962-1973, December 2022., 2022
Abstract Objectives Early‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well characterized cohort of patients with a biomarker‐based diagnosis.
Adrià Tort‐Merino, Neus Falgàs, Isabel E. Allen, Mircea Balasa, Jaume Olives, José Contador, Magdalena Castellví, Jordi Juncà‐Parella, Núria Guillén, Sergi Borrego‐Écija, Bea Bosch, Guadalupe Fernández‐Villullas, Oscar Ramos‐Campoy, Anna Antonell, Lorena Rami, Raquel Sánchez‐Valle, Albert Lladó   +16 more
wiley   +1 more source

Severe acute respiratory distress syndrome caused by Otsujito

Acute Medicine & Surgery, 2023
Background Kampo prescriptions can cause drug‐induced lung injury (DLI) and acute respiratory distress syndrome (ARDS). However, severe respiratory failure induced by Otsujito (OJT) is extremely rare. High‐dose steroid pulse therapy is generally given to
Nobuhisa Hirasawa, Hajime Nakae, Kasumi Satoh, Kenji Yoshida, Manabu Okuyama   +4 more
doaj   +1 more source

Abnormalities of the Halogen Bonds in the Complexes between Y₂CTe (Y = H, F, CH₃) and XF (X = F, Cl, Br, I)

Molecules, 2022
In this work, the hydrogen bonds and halogen bonds in the complexes between Y2CTe (Y = H, F, CH3) and XF (X = F, Cl, Br, I) have been studied by quantum chemical calculations. We found three interesting abnormalities regarding the interactions.
Ya-Qian Wang, Rui-Jing Wang, Qing-Zhong Li, Zhi-Wu Yu   +3 more
doaj   +1 more source

Zero-bias Deep Learning Enabled Quick and Reliable Abnormality Detection in IoT [PDF]

arXiv, 2021
Abnormality detection is essential to the performance of safety-critical and latency-constrained systems. However, as systems are becoming increasingly complicated with a large quantity of heterogeneous data, conventional statistical change point detection methods are becoming less effective and efficient.
arxiv  

An Abnormal Starfish [PDF]

Nature, 1886
A FEW weeks ago I dredged, off the north end of Arran, an interesting specimen of Porania pulvillus, Gray (= Goniaster templetoni, Forb.). It is rather more than 5 cm. in diameter, and one of the five short rays (that opposite to the madreporite), when viewed from the aboral surface, is seen to be distinctly bifurcated about 1 cm. from its termination.
openaire   +3 more sources

Abnormalities of the placenta [PDF]

BMC Pregnancy and Childbirth, 2012
Normal placental structure and function is essential for a healthy pregnancy; the placenta is responsible for nutrient and oxygen transport, removal of waste products, protection from infection, modulation of the maternal immune system and hormone production to maintain pregnancy.
openaire   +2 more sources

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source