Results 221 to 230 of about 77,071 (250)

Fitness for work and the aging workforce: medical assessment as a de facto mechanism of retirement in the United Kingdom after the abolition of the default retirement age. [PDF]

Front Public Health
Langlois A.
europepmc   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Reply: Methodological Considerations on Targeted Polymer Embolization in Obstructive Hypertrophic Cardiomyopathy. [PDF]

JACC Case Rep
Filho EM, Munhoz TS, Morais Alves CH, Xavier Júnior EF, Júnior SM.   +4 more
europepmc   +1 more source

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M6A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

Advanced Science, EarlyView.
Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen, Xin Liu, Gaoran Ge, Li Xu, Ziyu Zhang, Chang Lv, Hao Xu, Wenhao Li, Yi Qin, Qifeng Sheng, Qihan Wang, Hongxia Li, Jun Zhou, Huilin Yang, Dechun Geng   +14 more
wiley   +1 more source

The prospective multicenter study assessing safety and efficacy of mechanochemical ablation with the use of the Flebogrif catheter in patients with great saphenous vein incompetence: One year results. [PDF]

J Vasc Surg Venous Lymphat Disord
Zubilewicz T, Urbanek T, Janczak D, Jaworucka A, Terlecki K, Iłżecki M, Dorobisz T, Juśko M, Hawro P, Terlecki P.   +9 more
europepmc   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

The Effects of User Fee Exemptions on the Health System in Tanzania

Ndomba TS, Maluka SO.
europepmc   +1 more source

When the Solution May Be Worse Than the Problem: A Caution Against Permanent Daylight Saving Time, on Behalf of the Italian Academy of Sleep Medicine. [PDF]

J Sleep Res
Romigi A, Garbarino S, Ferini Strambi L, Lombardi C, Nobili L, Italian Academy of Sleep Medicine.   +5 more
europepmc   +1 more source