Results 11 to 20 of about 1,435 (159)

Wedelolactone, a Novel TLR2 Agonist, Promotes Neutrophil Differentiation and Ameliorates Neutropenia: A Multi-Omics Approach to Unravel the Mechanism. [PDF]

Adv Sci (Weinh)
Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Wang L, Li Z, Hu T, Li Q, Zhang L, Mei X, Qi X, Liu S, Kong W, Luo J, Wu A, Huang F, Li S, Dai S, Zhang C, Li R, Wu J.   +16 more
europepmc   +2 more sources

Low-Intensity Pulsed Ultrasound Promotes Osteogenesis in Porous Titanium Alloys Through miR-1187/BMP4 Pathway. [PDF]

FASEB J
The Schematic of LIPUS promotes osteogenesis of porous titanium alloys through inhibiting miR‐1187 and upregulating BMP4. ABSTRACT The repair of critical‐sized bone defects remains a significant clinical challenge. Low‐intensity pulsed ultrasound (LIPUS), in combination with porous titanium alloy (PTi) scaffolds, has emerged as a promising therapeutic ...
Qin L, Cao H, Liu X, Zhang D, Wu L.
europepmc   +2 more sources

First‐line Treatment With Bendamustine and Rituximab for Old and Frail Patients With Aggressive Lymphoma: Results of the B‐R‐ENDA Trial

HemaSphere, Volume 6, Issue 12, December 2022., 2022
The incidence of aggressive B‐cell lymphomas increases with age, but for elderly or frail patients not eligible for doxorubicin‐containing treatment standard therapy remains to be defined. In this prospective, multicenter, phase‐2 B‐R‐ENDA trial, we investigated the feasibility, toxicity, and efficacy of 8 cycles rituximab combined with 6 cycles ...
Friederike Braulke, Florian Zettl, Marita Ziepert, Andreas Viardot, Christoph Kahl, Gabriele Prange‐Krex, Agnieszka Korfel, Martin Dreyling, Alexander Bott, Ulrich Wedding, Dietmar Reichert, Maike de Wit, Frank Hartmann, Viola Poeschel, Norbert Schmitz, Mathias Witzens‐Harig, Wolfram Klapper, Andreas Rosenwald, Gerald Wulf, Bettina Altmann, Lorenz Trümper   +20 more
wiley   +1 more source

Morphological Characteristics and Correction of Long Tubular Bone Regeneration under Chronic Hyperglycemia Influence

Analytical Cellular Pathology, Volume 2020, Issue 1, 2020., 2020
Introduction. Unsatisfactory consequences of bone regeneration disorders in diabetes mellitus (DM) patients, their high prevalence, complication number, and difficulties in treatment require further study and deeper understanding of reparative osteogenesis mechanisms under chronic hyperglycemia and finding new effective and affordable approaches to ...
Yevhenii S. Dudchenko, Olena S. Maksymova, Vasyl S. Pikaliuk, Dmytro V. Muravskyi, Ludmila I. Kyptenko, Gennadii F. Tkach, Giovanni Tuccari   +6 more
wiley   +1 more source

ROSA: Realistic Open Security Architecture for active networks [PDF]

, 2002
Proceedings of IFIP-TC6 4th International Working Conference, IWAN 2002 Zurich, Switzerland, December 4–6, 2002.Active network technology enables fast deployment of new network services tailored to the specific needs of end users, among other features.
Bagnulo Braun, Marcelo Gabriel, Marifeli Sedano, Bagnulo, Marcelo, Bernardo Alarcos, María Calderón, Marcelo Bagnulo, Sedano, Marifeli, Calderón, María, Alarcos, Bernardo   +8 more
core   +2 more sources

Sosyal Medyada Çocuk: YouTube Oyun Kanalları Üzerine Dramaturjik Bir Analiz

Selçuk İletişim, 2021
Oyun, zaman ve yer kavramına bağlı olarak şekil değiştirerek evrensel boyutta varlığını her çağda sürdürmektedir. Dijitalleşme birçok alanda olduğu gibi oyunun da dönüşümünde rol oynamış ve oyunlar dijital ortamlarda varlık göstermeye başlamıştır. Sosyal
Fatma Kübra Astam, Tuğçe Esin Pınarbaşı   +1 more
doaj   +1 more source

Studies on a small collection of planorbid snails from southern south America

Revista da Sociedade Brasileira de Medicina Tropical, 1969
Snails belonging to Biomphalaria genus were collected from some regions of Southern South America as follows: Resistencia, province of Chaco, Argentina; Assumpcion, Paraguay; Department of Maldonado of Caneloni, Uruguay; and Pôrto Alegre, Rio Grande do ...
Frederico S. Barbosa, Dalva A. Mello
doaj   +1 more source

An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension

Nature Communications, 2021
Pulmonary arterial hypertension is a progressive fatal disease characterized by pathological pulmonary artery remodeling. Here the authors show that the dysregulation of the activin A-bone morphogenetic protein receptor type 2 link in the endothelium is ...
Gusty R. T. Ryanto, Koji Ikeda, Kazuya Miyagawa, Ly Tu, Christophe Guignabert, Marc Humbert, Tomoyuki Fujiyama, Masashi Yanagisawa, Ken-ichi Hirata, Noriaki Emoto   +9 more
doaj   +1 more source

HÜCRESEL SİSTEMLER

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2003
Bu çalışmada, GSM'de hücre yapısı ve hücreplanJaınası incelenmiştir. Mobil telefon sistemlerindehaberleşmenin yapılacağı alanın hücre adı verilenküçüllt; alanlara bölündüğü, GSM hücrelerininplanıanınasının yerleşim bölgelerinin özeJiilderinegöre ...
Levent Gökrem, Abdullah Ferikoğlu
doaj   +1 more source

Reconstruction of radial bone defect using gelatin sponge and a BMP-2 combination graft [PDF]

BMB Reports, 2013
Many bioactive molecules like recombinant human bonemorphogenetic protein 2 (rhBMP-2) have been developed formineralized bone grafts, for which proper scaffolds arenecessary to successfully apply the bioactive molecules.
Seong-Gon Kim, Jae-Hwan Jeong, Xiangguo Che, Yong-Tae Park, Sang-Woon Lee, Eun-Sun Jung, Senyon Choe, Je-Yong Choi   +7 more
doaj   +1 more source