Results 61 to 70 of about 22,260 (249)

Early prediction of multiple organ failure for sepsis patients based on machine learning algorithms

open access: yesJournal of Intelligent Medicine, EarlyView.
Abstract In recent years, there has been a notable rise in sepsis incidence leading to more multiple organ failure and higher mortality. The lack of effective treatments for sepsis highlights the importance of early prediction in preventing multiple organ failure. This study aimed to develop a model for the early prediction of multiple organ failure in
Runnan He   +11 more
wiley   +1 more source

Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease

open access: yesJournal of Periodontology, EarlyView.
Abstract Background Emerging evidence supports a bidirectional link between periodontitis and inflammatory bowel disease (IBD). To investigate this relationship, experimental models commonly use dextran sodium sulfate (DSS) to induce colitis. However, DSS is presumed to selectively affect the colon, and its potential off‐target effects on the oral ...
Himanshi Tanwar   +11 more
wiley   +1 more source

Cloning, expression and activity of ATP-binding protein in Bacillus thuringiensis toxicity modulation against Aedes aegypti

open access: yesParasites & Vectors, 2019
Background Bacillus thuringiensis israelensis (Bti) is a widely used mosquitocidal microbial pesticide due to its high toxicity. ATP-binding proteins (ABP) are prevalently detected in insects and are related to reaction against Bti toxins.
Guo-hui Zhao   +14 more
doaj   +1 more source

Sentinel events in pediatric hepatology: A pilot simulation curriculum

open access: yesJPGN Reports, EarlyView.
Abstract Objectives Sentinel hepatology events require robust prior experience to accurately diagnose and manage. Given the rarity of complex pediatric liver disease, gastroenterology (GI) fellows do not uniformly get exposure to these patients.
Anne Lyon   +7 more
wiley   +1 more source

Optical Skyrmions with Tunable or Reconfigurable Topology Using Spin‐Decoupled Metaoptics

open access: yesLaser &Photonics Reviews, EarlyView.
The work introduces advanced optical elements capable of generating and dynamically reconfiguring complex light patterns known as optical skyrmions. By precisely shaping light polarization at the nanoscale, a single engineered metasurface can generate and manipulate robust and tunable polarization textures in an efficient and scalable way.
Andrea Vogliardi   +5 more
wiley   +1 more source

Clinical Outcomes of Escherichia coli Acute Bacterial Prostatitis: A Comparative Study of Oral Sequential Therapy with β-Lactam Versus Quinolone Antibiotics

open access: yesAntibiotics
Background/Objectives: Optimal management of acute bacterial prostatitis (ABP) remains uncertain, but the use of antibiotics with good prostatic tissue penetration is critical to prevent recurrence and chronic progression.
Laura Gisbert   +7 more
doaj   +1 more source

Criação e consolidação da revista brasileira de psiquiatria (RBP)

open access: yesDebates em Psiquiatria, 2016
A Revista Brasileira de Psiquiatria (RBP) foi criada no mesmo ano que a Associação Brasileira de Psiquiatria (ABP), há 50 anos. Entretanto, a revista sofreu solução de conti nuidade, provocando mudança de seu nome para Revista da ABP e, posteriormente ...
Helena M. Calil
doaj   +1 more source

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

open access: yesMovement Disorders, EarlyView.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson   +5 more
wiley   +1 more source

Innovative γ‐Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery

open access: yesSmall, EarlyView.
Identified through multi‐stage selection process, a formulation combining γ‐oryzanol and DLin‐KC2‐DMA, termed as OryKL, demonstrates unique nano‐structural features, highly efficient mRNA transfection and functional integrity during long‐term storage, enables broad biodistribution and distinct cell tropism following intravenous administration with no ...
Pengkai Shi   +12 more
wiley   +1 more source

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