Unveiling the Hidden Risks: An Update Decade-Long Analysis of Abraxane-Related Adverse Events From the FAERS Database [PDF]
International Journal of NanomedicineYue-Chen Zhao,1,2 Xin Li,3 Chao-Qun Wang,4 Yan Jiao,5 Yan-Nan Shen,2 Tie-Jun Wang,1,2,* Chao-He Zhang6,* 1Department of Radiation Oncology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2NHC Key Laboratory
Yan Jiao, Tiejun Wang, Yue-Chen Zhao
exaly +4 more sources
The colloidal stability of albumin-based drug delivery systems has a profound effect on tumoricidal activity [PDF]
Drug DeliveryHuman serum albumin (HSA) has attracted significant attention in drug delivery since the approval of Abraxane in 2005. Abraxane is a nanoparticle albumin-bound paclitaxel (nab-PTX) formulation. Although HSA offers advantages such as prolonged circulation
Guojun Xiong +3 more
doaj +2 more sources
Protein corona guided albumin-binding paclitaxel nanoparticles for treatment of intracranial tumors [PDF]
Scientific ReportsAlbumin-bound paclitaxel (Abraxane) exhibits potent antitumor activity, but its suboptimal pharmacokinetics and the restrictive blood-brain barrier (BBB) greatly limit the broader application of albumin-based paclitaxel formulations in intracranial ...
Yunsa Huo +5 more
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Albumin Nanoparticles in Cancer Therapeutics: Clinical Status, Challenges, and Future Directions [PDF]
PharmaceuticsCancer, a global health burden, is characterized by uncontrolled cell growth and metastasis, often resulting in debilitating treatments and mortality. While conventional therapeutic strategies have improved survival rates, they are limited by challenges ...
Hachemi Kadri +5 more
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Enhancement of drug delivery through fibroblast activation protein–targeted near-infrared photoimmunotherapy [PDF]
JCI InsightThe tumor microenvironment plays a key role in cancer progression and therapy resistance, with cancer-associated fibroblasts (CAFs) contributing to desmoplasia, extracellular matrix (ECM) remodeling, and elevated interstitial fluid pressure, all of which
Seitaro Nishimura +21 more
doaj +2 more sources
Nano-enabled strategies for targeted immunotherapy in gastrointestinal cancers [PDF]
Frontiers in ImmunologyGastrointestinal (GI) cancers remain a leading cause of global cancer morbidity and mortality, demanding novel therapeutic strategies that overcome existing limitations.
Chaofan Chen +4 more
doaj +2 more sources
Expanding on Abraxane Safety: Temporal Insights and Future Directions for Adverse Event Analysis [Letter] [PDF]
International Journal of NanomedicineFangcai Yang,1 Wukun Ge2 1Department of Clinical Nutrition, Ninghai First Hospital, Ningbo, Zhejiang, 315600, People’s Republic of China; 2Department of Clinical Pharmacy, Ninghai First Hospital, Ningbo, Zhejiang, 315600, People’s Republic of
Yang F, Ge W
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DCE-MRI-Derived Parameters in Evaluating Abraxane-Induced Early Vascular Response and the Effectiveness of Its Synergistic Interaction with Cisplatin. [PDF]
PLoS ONE, 2016 Our previous studies revealed molecular alterations of tumor vessels, varying from immature to mature alterations, resulting from Abraxane, and demonstrated that the integrin-specific PET tracer 18F-FPPRGD2 can be used to noninvasively monitor such ...
Xilin Sun +8 more
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Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp. [PDF]
PLoS ONE, 2015 P-glycoprotein (P-gp) can actively pump paclitaxel (PTX) out of cells and induces drug resistance. Abraxane, a nanoparticle (NP) formulation of PTX, has multiple clinical advantages over the single molecule form.
Minzhi Zhao +9 more
doaj +1 more source
PLoS ONE, 2021 We developed a novel preparative method for nanoparticle albumin-bound (nab) paclitaxel with high drug loading, which was based on improved paclitaxel solubility in polyethylene glycol (PEG) and self-assembly of paclitaxel in PEG with albumin powders ...
Yue Gao +15 more
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