Results 31 to 40 of about 121,156 (234)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Sarf Öğretisinde Kural Dışı Kullanım Nedenleri/علل مخالفة القياس في الدرس الصرفي
Kocaeli İlahiyat Dergisi, 2020 تتناول هذه الدراسة قضية مخالفة القياس في مباحث علم الصرف من خلال فهم طبيعة العلل التي كانت وراء تلك المخالفات، إذ ظاهرة ترك القياس ظاهرة غامضة لكنها واسعة الحضور في مصنَّفات علم الصرف، إذ يكاد لا يخلو باب من الأبواب الصرفية من ألفاظ خالفت القوانين ...
Mahmoud Abs
doaj
Statistical Analysis and Probabilistic Characterization of the Mechanical Behavior of ABS: Application of Student’s t-Distribution and Weibull Distribution [PDF]
MATEC Web of ConferencesThis study, presents a detailed of a statistical study of how acrylonitrile butadiene styrene (ABS) behaves mechanically when subjected to uniaxial tensile testing.
Lamarti Amal +2 more
doaj +1 more source
Rekayasa Mesin, 2020 Rapid prototyping is a group of techniques used to quickly scale physical parts or assemblies using three-dimensional computer-aided design (CAD) data.
Yopi Yusuf Tanoto +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
International Journal of Gerontology, 2017 Background: The leading high-risk state for diabetes mellitus (DM) – prediabetes – is increasing; however, a lack of information exists in oldest old subjects.
Glòria Padrós +16 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source