Results 141 to 150 of about 2,304,558 (334)
Risk factors for valproic acid resistance in childhood absence epilepsy
, 2009 AimsValproic acid (VPA) is reported to be effective for the control of absence seizures in 75% of children. The aim of this study was to determine the clinical and socio-demographic factors associated with VPA response in newly diagnosed childhood ...
Krajinovic, Maja +4 more
core +1 more source
Absence Epilepsy with Fast Rhythmic Atypical EEG
Pediatric Neurology Briefs, 2001 The medical files of 31 patients with absence epilepsy (AE) were reviewed at La Timone University Hospital, and Henri Gastaut/Saint Paul Hospital, Marseilles, France.
J Gordon Millichap
doaj +1 more source
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
The evaluation of interictal focal EEG findings in adult patients with absence seizures
, 2009 PurposeTo investigate the focal interictal EEG abnormalities in adult patients with absence seizures (ASs) and to identify their clinical, EEG and semiological correlates.MethodsFifty patients older than 18 years, diagnosed as having IGE with AS ...
Altındağ, Ebru +6 more
core +1 more source
Genetics of Absence Epilepsy and Febrile Seizures
Pediatric Neurology Briefs, 2003 In a large family with epilepsy studied at the University of Melbourne, Australia, FS in 18 children were inherited as autosomal dominant with 75% penetrance (GABA receptor subunit mutation on chromosome 5), and absence epilepsy in 8 required the GABA ...
J Gordon Millichap
doaj +1 more source
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
, 2010 Models of genetic absence epilepsy are resistant to secondary generalization of focal limbic seizures. This correlates with the postnatal development of spike-and-wave discharges (SWDs), a hallmark of absence seizures arising from a cortical focus in the
GÜLHAN, REZZAN, ONAT, FİLİZ
core +1 more source
Interhemispheric Functional Connectivity in Childhood Absence Epilepsy
Pediatric Neurology Briefs, 2011 Using a blood oxygen level-dependent resting functional connectivity approach to analyze EEG-fMRI data, the properties of bihemispheric brain networks in 16 patients with childhood absence epilepsy (CAE) were investigated during the interictal period, in
J Gordon Millichap
doaj +1 more source
Advanced Science, EarlyView.Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska +14 more
wiley +1 more source
Magnetic resonance spectroscopy of the thalamus in patients with typical absence epilepsy
, 2006 SummaryPurposeTo investigate possible neuronal dysfunction of the thalamus in patients suffering from typical absence epilepsy, using magnetic resonance spectroscopy (MRS). Special attention was paid to levels of N-acetylaspartate (NAA) and creatine (Cr),
Kuba, Robert +6 more
core +1 more source