Results 301 to 310 of about 2,037,182 (380)

Recombinant Human Neuregulin1‐β1 Significantly Reduces Schwannoma Growth in Mice

Annals of Neurology, EarlyView.
rhNRGβ1‐Replacement‐Therapy: Under physiological conditions, NRGβ1 is expressed on axons (in orange), where it activates ERBB2 receptors, facilitating successful nerve regeneration following injury. However, loss of NF2 leads to a reduction in NRGβ1‐expression and increased ErbB2 levels on Schwann cells (in green), which contributes to schwannoma ...
Julia P. Bischoff, Alexander Schulz, Christian Hagel, Robert Büttner, Michael Reuter, Waylan K. Bessler, D. Wade Clapp, Helen Morrison   +7 more
wiley   +1 more source

A Frank Assessment of SHANK: Impacts of Pathogenic Variations in SHANK3 on Preclinical Models of Phelan McDermid Syndrome

Autism Research, EarlyView.
ABSTRACT Although there are as many as 40 preclinical models of the neurodevelopmental disorder Phelan McDermid syndrome (PMS, or 22q13.3 deletion syndrome), detailed phenotypic analyses to compare the effects of different pathogenic variants and inform treatment design are lacking.
Vic Lin, Samantha M. Matta, Julia E. Dallman, Suzanne Hosie, Manon Moreau, Ashley E. Franks, Thomas Bourgeron, Elisa L. Hill‐Yardin   +7 more
wiley   +1 more source

Epilepsy-related functional brain network alterations are already present at an early age in the GAERS rat model of genetic absence epilepsy. [PDF]

Front Neurol
Wachsmuth L, Hebbelmann L, Prade J, Kohnert LC, Lambers H, Lüttjohann A, Budde T, Hess A, Faber C.   +8 more
europepmc   +1 more source

Altered directed functional connectivity in temporal lobe epilepsy in the absence of interictal spikes: A high density EEG study

Epilepsia, 2016
A. Coito, M. Genetti, F. Pittau, G. Iannotti, Aljoscha Thomschewski, Y. Höller, E. Trinka, R. Wiest, M. Seeck, C. Michel, Gijs Plomp, S. Vulliémoz   +11 more
semanticscholar   +1 more source

Comparison of Adulthood Outcomes in Autism Spectrum Disorder With and Without Regression: A Population‐Based Birth Cohort Study

Autism Research, EarlyView.
ABSTRACT The long‐term outcomes of regression in autism spectrum disorder (ASD) remain unclear. Previous evidence suggests that autistic individuals with regression have poorer adulthood outcomes across various indices than those without regression. We compared two groups—those with and without regression in ASD—among 168 participants from a population‐
Satoru Minami, Mitsuaki Iwasa, Hiroko Ohzono, Daimei Sasayama, Hideo Honda   +4 more
wiley   +1 more source

Paediatric rare diseases: Can large language models assist off‐label prescribing?

British Journal of Clinical Pharmacology, EarlyView.
Aims To evaluate the effectiveness and reliability of large language models (LLMs) in retrieving and synthesizing biomedical information to support off‐label drug prescribing in paediatric rare diseases, and to compare their performance with human‐authored references in terms of scientific rationale, adverse events and drug interactions.
Anna Flamigni, Giulia Zamagni, Gilda Paternuosto, Anna Arbo   +3 more
wiley   +1 more source

Automated diagnosis of temporal lobe epilepsy in the absence of interictal spikes

NeuroImage: Clinical, 2017
T. Verhoeven, A. Coito, Gijs Plomp, Aljoscha Thomschewski, F. Pittau, E. Trinka, R. Wiest, K. Schaller, C. Michel, M. Seeck, J. Dambre, S. Vulliémoz, P. van Mierlo   +12 more
semanticscholar   +1 more source

Pregabalin dependence, withdrawal, suicidality and psychosis reports: A disproportionality analysis of the Australian adverse events database

British Journal of Clinical Pharmacology, EarlyView.
Aims Globally, Australia has the highest per capita consumption rate of pregabalin, commonly prescribed for neuropathic pain. Emerging evidence suggests pregabalin may be associated with the onset or recurrence of several potentially life‐threatening psychiatric events in some individuals.
Amy G. McNeilage, Ali Gholamrezaei, Bridin Murnion, Suzanne Nielsen, Claire E. Ashton‐James   +4 more
wiley   +1 more source

Variations in Human Trigeminal and Facial Nerve Branches and Foramina Identified by Dissection and Microcomputed Tomography

Clinical Anatomy, EarlyView.
ABSTRACT The aim of this study was to identify branches of the trigeminal and facial nerves (FNs) relevant to surgical incisions and injections and the scalp block techniques in the frontotemporal region, and to determine their relationships with superficial vascular structures and bony landmarks.
Hannah L. Grimes, Valentina Pizzuti, Maria A. Wright, Kane P. J. Colston, Thomas Santarius, Susan Jones   +5 more
wiley   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source