Results 61 to 70 of about 128,227 (258)

Sudden unexpected death after acute symptomatic seizures in a patient on mechanical ventilation

Acta Epileptologica, 2020
Background The mechanism of sudden unexpected death in epilepsy remains poorly understood. Seizure induced cardiac arrhythmia, central and obstructive apneas have been proposed as possible causes of death.
Raisa C. Martinez, Naoum P. Issa, Shasha Wu, Xi Liu, Sandra Rose, James X. Tao   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Serum Interleukin-6 as a Potential Biomarker in Absence Epilepsy

Haseki Tıp Bülteni
Aim: The role of inflammation in absence epilepsy remains a subject of debate. The present study aims to assess the role of interleukin-6 (IL-6) in absence epilepsy by determining serum IL-6 levels of children with absence epilepsy and the association ...
Gunce Basarir, Anil Baysoy, Sema Bozkaya Yilmaz, Ayfer Colak, Nihal Olgac Dundar, Pinar Gencpinar   +5 more
doaj   +1 more source

Effects Of Probiotic Consumption On Absence Seizures

Journal of the Turkish Epilepsi Society, 2017
Objectives:Probiotics are microorganisms of intestinal microflora that are beneficial for human health. Childhood absence epilepsy has 2 validated rat models: Genetic Absence Epilepsy Rats from Strasbourg (GAERS) and Wistar Albino Glaxo from Rijswijk (WAG/Rij). To date, there have been no clinical or experimental studies of the effects of probiotics on
Doğan, Mehmet Can, Onat, Filiz, Karamahmutoğlu, Tuğba, Esenkar, Duygu, Akkol, Serdar, Doğan, Handan   +5 more
openaire   +5 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Investigation of ECG Changes in Absence Epilepsy on WAG/ Rij Rats

Basic and Clinical Neuroscience, 2015
Introduction: Seizures are symptoms associated with abnormal electrical activity in electroencephalogram (EEG). The present study was designed to determine the effect of absence seizure on heart rate (HR) changes in electrocardiogram (ECG).
Fatemeh Es'haghi, Parviz Shahabi, Javad Frounchi, Mina Sadighi, Hadi Yousefi   +4 more
doaj  

Comparative Effectiveness of 100 mg/kg Levetiracetam Injection in Two Different Epilepsy Models: Temporal Lobe Epilepsy and Genetic Absence Epilepsy

Archives of Epilepsy
Objective: Levetiracetam (LEV) is a broad-spectrum anti-seizure drug primarily prescribed for partial seizures. We aimed to compare the effects of LEV in two epilepsy models: the kindling model for temporal lobe epilepsy and the Genetic Absence Epilepsy ...
Elif Tuğçe Erdeve, Filiz Onat, Nihan Çarçak   +2 more
doaj   +1 more source