Results 61 to 70 of about 923,263 (264)
Tephrochronology and Absolute Age Determination
Most tephrochronological studies based upon absolute ages are derived from historical records of eruption and radiocarbon dates from Holocene and Pleistocene times. However, unless associated with some organic matters whose ages are younger than 35, 000 years old, tephra layers usually could not be dated.Recently Kigoshi explored the possibility that ...
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Racism and State Formation in the Age of Absolutism
Abstract This essay explores four questions through a critical dialogue with Black Marxist, Decolonial, and Political Marxist accounts of racism. First, is it possible to speak of racism before the advent of colonisation in the Americas? Second, what were the determinants for the production of these earlier modalities of racism? Third, who were the key
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Hipparcos Subdwarfs and Globular Cluster Ages: Towards Reliable Absolute Ages [PDF]
The maximum age of galactic globular clusters provides the best observational constraint on the minimum age of the Universe. One of the main “missing link” in the globular cluster age determination has been the lack of a precise calibration, with local subdwarfs, of the position of the subdwarf sequence at different [Fe/H].Hipparcos data may change ...
F. Pont, M. Mayor, C. Turon
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
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The 3.5 Ga Siurua trondhjemite gneiss in the Archaean Pudasjärvi Granulite Belt, northern Finland [PDF]
In the Archaean Pudasjärvi Complex the pyroxene-bearing rocks are considered to form a belt, the Pudasjärvi Granulite Belt (PGB). The major rock types of the PGB are meta-igneous mafic and felsic granulites, and trondhjemite gneisses Red alaskites, white
T. Mutanen, H. Huhma
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Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
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Metastatic niche shaped by host factors influences disseminated cancer cell fate
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
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Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
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In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
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Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
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