Results 251 to 260 of about 95,952 (294)

Absolute bioavailability of oral theophylline

American Journal of Health-System Pharmacy, 1977
The absolute bioavailability of theophylline was investigated by comparing the areas under concentration-time curves for intravenous theophylline with a plain uncoated anhydrous theophylline tablet and a theophylline solution. Twenty asthmatic adults received approximately 7.5 mg/kg theophylline intravenously over 30 minutes; either seven days before ...
L, Hendeles, M, Weinberger, L, Bighley
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Absolute Bioavailability of Cefixime in Man

The Journal of Clinical Pharmacology, 1988
In a four‐way cross‐over study, the absolute bioavailability of cefixime was determined in 16 healthy volunteers. Each subject received a single 200‐mg dose as an intravenous (IV) and oral solution, and 200‐mg and 400‐mg capsule doses of the drug. Blood and urine samples were collected for 24 hours after each dose.
R D, Faulkner, P, Fernandez, G, Lawrence, L L, Sia, A J, Falkowski, A I, Weiss, A, Yacobi, B M, Silber   +7 more
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Absolute Bioavailability of Bromfenac in Humans

Annals of Pharmacotherapy, 1997
ObjectiveTo estimate absolute bioavailability of bromfenac and to compare its pharmacokinetics after intravenous and oral administration.DesignThis was a randomized, open-label, single-dose, crossover study conducted under fasting conditions with a washout period of at least 48 hours between doses.
K, Gumbhir-Shah, W H, Cevallos, S A, DeCleene, C E, Halstenson, J M, Korth-Bradley   +4 more
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Kinetics and absolute bioavailability of atenolol

Clinical Pharmacology & Therapeutics, 1979
Twelve healthy volunteers received four single doses of atenolol (25‐, 25‐, and 100‐mg oral solutions and a 50‐mg intravenous infusion), each dose separated by at least one week. Blood and urine assayed for atenolol by a high pressure liquid chromatography (HPLC) method.
W D, Mason, N, Winer, G, Kochak, I, Cohen, R, Bell   +4 more
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Linezolid absolute bioavailability and the effect of food on oral bioavailability

Biopharmaceutics & Drug Disposition, 2001
AbstractLinezolid is a novel oxazolidinone antibiotic that has a spectrum of activity encompassing a variety of Gram‐positive bacteria. The objectives of this study were twofold: (1) to compare the absorption of linezolid tablets given immediately following a high‐fat meal with the absorption of tablets administered while fasting, and (2) to assess the
I R, Welshman, T A, Sisson, G L, Jungbluth, D J, Stalker, N K, Hopkins   +4 more
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Pharmacokinetics and absolute bioavailability of diltiazem in humans

Klinische Wochenschrift, 1984
Six healthy male volunteers received single doses of diltiazem hydrochloride on three occasions separated by at least 10 days. Modes of administration were: 10-minute intravenous infusion of a 20-mg dose; oral administration of 120 mg in solution form; and oral administration of 120 mg as two 60-mg sustained-release tablets.
H R, Ochs, M, Knüchel
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The pharmacokinetics and absolute bioavailability of selegiline in the dog

Biopharmaceutics & Drug Disposition, 1994
AbstractSelegiline is beneficial to Parkinsonian patients as an adjunct to levodopa therapy. Currently no pharmacokinetic data are available for selegiline in the literature, mainly due to lack of analytical methods that can measure concentrations below 10 ng mL−1 in plasma.
I, Mahmood, D K, Peters, W D, Mason
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Absolute bioavailability of amiodarone in normal subjects

Clinical Pharmacology and Therapeutics, 1985
The relative and absolute bioavailability of different oral forms of amiodarone was examined in 12 subjects. The doses were 5 mg/kg iv, two 200-mg commercial tablets by mouth, two 200-mg tablets (new formulation) by mouth, and 400 mg in a drinkable solution.
S, Pourbaix, Y, Berger, J P, Desager, M, Pacco, C, Harvengt   +4 more
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Absolute bioavailability and stereoselective pharmacokinetics of doxepin

Xenobiotica, 2002
1. Commercial doxepin contains geometric isomers in the proportions Z:E = 15:85. Z-doxepin and its metabolite Z-N-desmethyldoxepin are both active antidepressants, whereas the corresponding E-isomers are less active therapeutically. 2. The present pharmacokinetic study was a balanced, randomized, two-treatment, two-period, two-sequence crossover design
J-H, Yan, J W, Hubbard, G, McKay, E D, Korchinski, K K, Midha   +4 more
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Absolute Bioavailability of Osimertinib in Healthy Adults

Clinical Pharmacology in Drug Development, 2018
AbstractOsimertinib is a third‐generation, central nervous system–active, epidermal growth factor receptor–tyrosine kinase inhibitor (EGFR‐TKI) selective for EGFR‐TKI sensitizing and T790M resistance mutations. This phase 1, open‐label study (NCT02491944) investigated absolute bioavailability and pharmacokinetics (PK) of oral and intravenous (IV ...
Karthick, Vishwanathan, Karen, So, Karen, Thomas, Alex, Bramley, Stephen, English, Jo, Collier   +5 more
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