Results 261 to 270 of about 95,952 (294)

Absolute bioavailability and pharmacokinetics of avosentan in man

Int. Journal of Clinical Pharmacology and Therapeutics, 2009
Avosentan is a potent, selective endothelin A receptor blocker. The pharmacokinetics of avosentan were investigated in healthy male and female volunteers, following oral and i.v. administration of single doses of avosentan and its absolute bioavailability was determined.In a randomized, balanced open-label, three-period oral crossover study, 26 healthy
W, Dieterle, T, Hengelage
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The absolute bioavailability of microcrystalline theophylline

Current Medical Research and Opinion, 1979
SummaryA study was carried out to investigate the variation in the systemic availability of theophylline after ingestion of a new microcrystalline tablet (‘Theolair”). Serum concentrations obtained after oral administration of the drug were compared with those after intravenous infusion of aminophylline in the same patient. The absolute bioavailability
Jonkman, J.H.G., Berg, W.C., Schoenmaker, R., Greving, J.E., de Zeeuw, R.A., Orie, N.G.M.   +5 more
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Absolute Intramuscular, Oral, and Rectal Bioavailability of Alizapride

Journal of Pharmaceutical Sciences, 1984
A study was designed to estimate the absolute bioavailability of alizapride after intramuscular injection, oral administration as a solution or a tablet, and rectal administration as a suppository compared with that after intravenous injection. A balanced incomplete block-design trial was adopted.
G, Houin, J, Barre, J P, Tillement
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Absolute and Relative Bioavailability of Oral Acetaminophen Preparations

Journal of Pharmaceutical Sciences, 1983
Eighteen healthy volunteers received single 650-mg doses of acetaminophen by 5-min intravenous infusion, in tablet form by mouth in the fasting state, and in elixir form orally in the fasting state in a three-way crossover study. An additional eight subjects received two 325-mg tablets from two commercial vendors in a randomized crossover fashion ...
B, Ameer, M, Divoll, D R, Abernethy, D J, Greenblatt, L, Shargel   +4 more
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Absolute Bioavailability and Absorption Profile of Cyanamide in Man

Journal of Pharmacokinetics and Biopharmaceutics, 1999
A pharmacokinetic study of cyanamide, an inhibitor of aldehyde dehydrogenase (EC1.2.1.3) used as an adjuvant in the aversive therapy of chronic alcoholism, has been carried out in healthy male volunteers following intravenous and oral administration. Cyanamide plasma levels were determined by a sensitive HPLC assay, specific for cyanamide.
H, Colom, J, Pruñonosa, C, Peraire, J, Domenech, O, Azcona, J, Torrent, R, Obach   +6 more
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Pharmacokinetics, Absolute Bioavailability, and Absorption Characteristics of Lamivudine

The Journal of Clinical Pharmacology, 1995
Lamivudine is a novel cytosine nucleoside analog, reverse transcriptase inhibitor that has shown activity against human immunodeficiency virus (HIV) types 1 and 2 and hepatitis B virus in vitro. This study was conducted to compare the absolute bioavailability, pharmacokinetics, and absorption characteristics of oral solution, 100‐mg capsule, and 100‐mg
G J, Yuen, D M, Morris, P K, Mydlow, S, Haidar, S T, Hall, E K, Hussey   +5 more
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Absolute bioavailability of pirenzepine in intensive care patients

European Journal of Clinical Pharmacology, 1990
The absolute bioavailability (f) of pirenzepine was determined in 27 intensive care patients receiving the drug for prophylaxis and therapy of upper gastrointestinal tract bleeding. A multiple oral and intravenous dosage regimen and the times of blood sampling were adapted to individual conditions and treatment.
P, Tanswell, F, Hofgärtner, G, Bozler, H, Giesler, G, Allmendinger, E, Schmid   +5 more
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Absolute Bioavailability of Oral and Intramuscular Diazepam

Anesthesia & Analgesia, 1983
Twenty-two healthy volunteers aged 20-78 years received single 5-mg doses of diazepam by intravenous injection, by mouth in the fasting state, and by a deltoid intramuscular injection. The kinetic profile of diazepam by each route was determined from multiple plasma diazepam concentrations measured 7-14 days after each dose. After intravenous injection,
M, Divoll, D J, Greenblatt, H R, Ochs, R I, Shader   +3 more
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[Absolute bioavailability of theophylline (Euphylline)].

Fortschritte der Medizin, 1981
The pharmacokinetics and bioavailability of theophylline have been investigated in eight healthy subjects following application of the drug in form of a tablet, a retard tablet (enteric-coated), and a suppository (Euphyllin) in comparison with an intravenous preparation.
A, Somogyi, R, Gugler
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Absolute bioavailability of digoxin tablets.

Arzneimittel-Forschung, 1979
Ten healthy male volunteers each received 0.5 mg digoxin orally and i.v. in a randomised, cross-over sequence with at least two weeks between doses. Plasma concentration and cumulative urinary excretion of digoxin were measured up to 6 and 144 h, respectively, after administration using a radioimmunoassay method. Absolute bioavailability (i.e.
T, Beveridge, E, Nüesch, E E, Ohnhaus
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