Results 1 to 10 of about 839,062 (317)

Absolute Configuration and Chiroptical Properties of Flexible Drug Avapritinib [PDF]

Pharmaceuticals
Background/Objective: Avapritinib is an orally bioavailable tyrosine kinase inhibitor and was approved by the FDA in 2020 for gastrointestinal stromal tumor treatments.
Ya-Dong Yang, Chen Zhao, Liang-Peng Li, Yi-Xin Lv, Bei-Bei Yang, Xin Li, Ru Wang, Li Li   +7 more
doaj   +2 more sources

Redetermination and absolute configuration of pruniflorone M monohydrate

Acta Crystallographica Section E, 2011
The title xanthone known as pruniflorone M (systematic name: (2R)-5,10-dihydroxy-2-hydroxymethyl-1,1-dimethyl-1H-furo[2,3-c]xanthen-6-one), crystallized in a monohydrate form, C18H16O6·H2O.
Hoong-Kun Fun, Suchada Chantrapromma, Nawong Boonnak, Chatchanok Karalai, Kan Chantrapromma   +4 more
doaj   +2 more sources

Interpreting vibrational circular dichroism spectra: the Cai•factor for absolute configuration with confidence [PDF]

Journal of Cheminformatics, 2023
Vibrational circular dichroism (VCD) spectroscopy can generate the data required for the assignment of absolute configuration, but the spectra are hard to interpret.
Jonathan Lam, Richard J. Lewis, Jonathan M. Goodman   +2 more
doaj   +2 more sources

Crystal structure and absolute configuration of (3aS,4S,5R,7aR)-2,2,7-trimethyl-3a,4,5,7a-tetrahydro-1,3-benzodioxole-4,5-diol [PDF]

Acta Crystallographica Section E: Crystallographic Communications, 2015
The absolute configuration of the title compound, C10H16O4, determined as 3aS,4S,5R,7aR on the basis of the synthetic pathway, was confirmed by X-ray diffraction.
Mario A. Macías, Leopoldo Suescun, Enrique Pandolfi, Valeria Schapiro, Gaurao D. Tibhe, Álvaro W. Mombrú   +5 more
doaj   +2 more sources

3-Nitroatenolol: First Synthesis, Chiral Resolution and Enantiomers’ Absolute Configuration [PDF]

Molecules
4-Nitro and 7-nitro propranolol have been recently synthesized and characterized by us. (±)-4-NO2-propranolol has been shown to act as a selective antagonist of 6-nitrodopamine (6-ND) receptors in the right atrium of rats.
Rosa Sparaco, Pierfrancesco Cinque, Antonia Scognamiglio, Angela Corvino, Giuseppe Caliendo, Ferdinando Fiorino, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Beatrice Severino, Paolo Luciano, Marcello Casertano, Anna Aiello, Gustavo Yuri Martins Viegas, Gilberto De Nucci, Francesco Frecentese   +15 more
doaj   +2 more sources

Synthesis, crystal structure and absolute configuration of (3aS,4R,5S,7aR)-7-(but-3-en-1-yn-1-yl)-2,2-dimethyl-3a,4,5,7a-tetrahydro-2H-1,3-benzodioxole-4,5-diol [PDF]

Acta Crystallographica Section E: Crystallographic Communications
The absolute configuration of the title compound, C13H16O4, determined as 1S,2R,3S,4R based on the synthetic pathway, was confirmed by single-crystal X-ray diffraction.
Alejandro Peixoto de Abreu Lima, Enrique Pandolfi, Valeria Schapiro, Leopoldo Suescun   +3 more
doaj   +2 more sources

Biological Properties and Absolute Configuration of Flavanones From Calceolariathyrsiflora Graham [PDF]

Frontiers in Pharmacology, 2020
Flavanones (–)-(2S)-5,4’-dihydroxy-7-methoxyflavanone (1) and (–)-(2S)-5,3’,4’-trihydroxy-7-methoxyflavanone (2) were isolated from the extracts of Calceolariathyrsiflora Graham, an endemic perennial small shrub growing in the central zone of Chile.
Ernesto Valdés, César González, Katy Díaz, Yesseny Vásquez-Martínez, Yesseny Vásquez-Martínez, Carolina Mascayano, Claudia Torrent, Francisco Cabezas, Sophia Mejias, Margarita Montoya, Marcelo Cortez-San Martín, Marcelo A. Muñoz, Pedro Joseph-Nathan, Mauricio Osorio, Lautaro Taborga   +14 more
doaj   +2 more sources

A Revised Structure and Assigned Absolute Configuration of Theissenolactone A [PDF]

Molecules, 2020
Antimicrobial bioassay-guided fractionation of Microcera larvarum led to the isolation of a γ-lactone with a furo[3,4-b]pyran-5-one bicyclic ring system (1) and three known compounds, (3S,4R)-4-hydroxymellein (2), (3S,4S)-4-hydroxymellein (3) and 7 ...
Melissa M. Cadelis, Soeren Geese, Lauren Gris, Bevan S. Weir, Brent R. Copp, Siouxsie Wiles   +5 more
doaj   +2 more sources

All-Heteroatom-Substituted Carbon Spiro Stereocenters: Synthesis, Resolution, Enantiomeric Stability, and Absolute Configuration. [PDF]

J Am Chem Soc
Viudes O, Besnard C, Siegle AF, Trapp O, Bürgi T, Pescitelli G, Lacour J.   +6 more
europepmc   +2 more sources

Chiroptical Signature and Absolute Configuration of Tröger’s Base-Based Triangular Macrocycles [PDF]

ACS Omega
Luis Palomo, Carlos M. Cruz, Araceli G. Campaña, Bo Jiang, Jishan Wu, Juan Casado, Francisco J. Ramírez   +6 more
doaj   +2 more sources