Results 61 to 70 of about 839,062 (317)

The Absolute Configuration of Sarkomycin.

Chemical and Pharmaceutical Bulletin, 1963
(+)-3-Oxocyclopentanecarboxylic acid was chemically correlated with (+)-3-carboxyadipic acid and with (+)-3-methylcyclopentanone, both of which are of known absolute configurations. This correlation established that the natural sarkomycin, (-)-2-methylene-3-oxocyclopentanecarboxylic acid, is represented by the formula (XXXII), of which C-1 is S.
Y, SATO, S, NISHIOKA, O, YONEMITSU, Y, BAN   +3 more
openaire   +3 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Crystal structure of (R)-6-fluoro-2-[(S)-oxiran-2-yl]chroman

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C11H11FO2, is a building block in the synthesis of the active pharmaceutical ingredient dl-nebivolol. The synthesis starting from the enantiomerically pure (R)-6-fluoro-4-oxo-3,4-dihydro-2H-chromene-2-carboxylic acid resulted in a ...
Yoann Rousselin, Hugo Laureano, Alexandre Clavel   +2 more
doaj   +1 more source

Absolute configuration of (S)-(+)-[(Benzyloxymethyl)(tert-butyl)methylsilyl] methyl ketone [PDF]

, 1996
The absolute configuration of the title compound was confirmed by an X-ray crystal structure analysis of (R)-(+)-[(benzyloxymethyl)(tert-butyl)methylsilyl] methyl ketone 2,4,6-triisopropylphenylsulfonylhydrazone, C30H48N203SSi, reported herein.
Antonia Hess (3589880), Franziska Nippert (3589883), Klaus-Dieter Schlüter (339076), Martin Weber (1941247), Rolf Schreckenberg (339079)   +4 more
core   +4 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Crystal structure and absolute configuration of preaustinoid A1

Acta Crystallographica Section E: Crystallographic Communications, 2015
The absolute structure of the title compound preaustinoid A1 [systematic name: (5aR,7aS,8R,10S,12R,13aR,13bS)-methyl 10-hydroxy-5,5,7a,10,12,13b-hexamethyl-14-methylene-3,9,11-trioxohexadecahydro-8,12-methanocycloocta[3,4]benzo[1,2-c]oxepine-8 ...
Andrea Stierle, Donald Stierle, Daniel Decato   +2 more
doaj   +1 more source

(Sp)-1-Diphenylphosphanyl-2-{(S)-[2-(diphenylphosphanyl)phenyl]hydroxymethyl}ferrocene [PDF]

, 2008
The absolute configuration of the title compound, [Fe(C5H5)(C36H29OP2)], is Sp at the ferrocene group and S at the asymmetric C atom. Both P atoms have a trigonal-pyramidal conformation.
Bats, Jan W., Doppiu, Angelino, Hashmi, A. Stephen K., Rivas Nass, Andreas   +3 more
core   +3 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

The reflection invariance problems in stereochemical nomenclature for absolute configuration

Chemistry Teacher International, 2023
Genesis of chirality and its link to the origin of life continue to intrigue scientists. Chirality also plays an important role in medicine with the advent of chiral drugs and the consequent importance of asymmetric synthesis.
Bhattacharya Prabuddha, Basak Amit
doaj   +1 more source

Organocatalytic stereodivergent synthesis of β,β-disubstituted-α-aminoacids [PDF]

, 2017
In this work, we present an organocatalytic stereodivergent synthesis of β,β-disubstituted-α-aminoacids using arylidene azlactones as starting materials.
Martinelli, Ada
core