Results 41 to 50 of about 388 (219)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
On Indexed Absolute Matrix Summability of an Infinite Series [PDF]
, 2018 Some results have been established on absolute index Riesz summability factor of an infinite series. Furthermore, these kind of results can be extended by taking other parameters and an absolute index matrix summability factor of an infinite series or ...
Mishra, Lakshmi N. +4 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
On a recent result on absolute summability factors [PDF]
, 2005 In this paper, a general theorem of |A|k summability factors is presented. This generalization is accomplished by replacing the weighted mean matrix in Mazhar’s theorem in [S.M.
Savas, E, Savaş, Ekrem
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Paranormed spaces of absolute tribonacci summable series and some matrix transformations
Dera Natung Government College Research JournalIn a more recent paper, the absolute series space I T_\Phi I_q which is defined as the domain of the matrix corresponding to the absolute Tribonacci summability in the well-known space l_q has taken place in the literature (Gökçe, in press).
Fadime Gökçe
doaj +1 more source
Necessary conditions for absolute double matrix summability factors
Periodica Mathematica Hungarica, 2011 The authors extend their own findings for absolute summability transformed series (published earlier, see [\textit{E. Savaş} and \textit{B. E. Rhoades}, Indian J. Pure Appl. Math. 33, No. 7, 1003--1009 (2002; Zbl 1015.40001)]) to bounded double series transformed by triangular matrices. Their results apply to double weighted mean matrices, specifically
Savas, Ekrem, Rhoades, B. E.
openaire +4 more sources
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source