Results 171 to 180 of about 67,271 (245)

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Integrated Bioinformatics Analysis Identifies FCER1G, IL1R2, and BST1 as Diagnostic Biomarkers and Therapeutic Targets in Sepsis

Journal of Clinical Laboratory Analysis, EarlyView.
Integrative bioinformatics and experimental validation of FCER1G, IL1R2, and BST1 as biomarkers and therapeutic targets in neonatal sepsis. ABSTRACT Background Sepsis remains difficult to diagnose since blood culture has low sensitivity and current biomarkers lack sufficient specificity.
Junjie Li, Guanghui Xiu, Ping Liu, Xianzhong Chen, Kailv Zhou, Yunfeng Yang   +5 more
wiley   +1 more source

Prognostic Significance of Peripheral Blood Neutrophil‐To‐Lymphocyte Ratio (NLR), Monocyte‐To‐Lymphocyte Ratio (MLR), and Platelet‐To‐Lymphocyte Ratio (PLR) in Patients With Multiple Myeloma: A Retrospective Cohort Study

Journal of Clinical Laboratory Analysis, EarlyView.
This graphical abstract illustrates the prognostic significance of systemic inflammatory markers in Multiple Myeloma (MM). The left panel depicts the immunosuppressive tumor microenvironment, where abundant neutrophils and M2 macrophages promote MM cell survival while lymphocytes are depleted.
Lihong Zhang, Bing Ma, Jingyu Zhang
wiley   +1 more source

Optimizing Laboratory Autoverification in Complete Blood Count Testing Using Machine Learning: A Performance Evaluation Study

Journal of Clinical Laboratory Analysis, EarlyView.
This cross‐sectional study evaluated the feasibility of applying machine learning for complete blood count autoverification. Among 63,201 CBC results, the XGBoost model achieved higher sensitivity and predictive values compared with the traditional rule‐based system. ABSTRACT Background Autoverification improves laboratory efficiency by reducing manual
Sinsorn Srirujee, Peempol Chokchaipermpoonphol   +1 more
wiley   +1 more source

Peripheral hematological landscapes as biomarkers for detecting postoperative progression in glioblastoma multiforme: a multivariable risk scoring approach. [PDF]

J Neurooncol
Tzeng CC, Chung MW, Huang YC, Chen KT, Lin YJ, Hsu PW, Chuang CC, Wei KC, Lee CC.   +8 more
europepmc   +1 more source

Age‐related local versus systemic early phase wound healing dynamics following free gingival graft harvest

Journal of Periodontology, EarlyView.
Abstract Background Free palatal gingival grafts (FGG) are commonly harvested during mucogingival procedures. The present study investigates age‐related local and systemic early secondary wound healing outcomes, following FGG harvest in a rat model. Methods A 4.2 mm diameter defect was created in the palate of 24 younger (2 m) and 24 older (6 m) Wistar
Maayan Atzmon‐Shavit, Marilena Vered, Michael Saminsky, Liat Chaushu   +3 more
wiley   +1 more source

Establishing Reference Intervals for White Blood Cell and Absolute Neutrophil Counts in Duffy Null Individuals. [PDF]

Hematol Rep
Barouqa M, Ashfaq MA, Jiang KJ, Kilic H, Dela Cruz N, Khalid A, Yassa ME.   +6 more
europepmc   +1 more source

Abdominal pain in pediatric immunoglobulin A vasculitis: Risk factors and severity predictors in a multicenter cohort

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To identify risk factors for abdominal pain and predictors of complicated abdominal pain in pediatric immunoglobulin A vasculitis (IgAV). Methods Retrospective multicenter study including children and adolescents (≤18 years) fulfilling the European League Against Rheumatism/Pediatric Rheumatology International Trials Organization ...
Francisco Hugo Rodrigues Gomes, Natalia Maronese, Leticia Lizardo Magalhaes, Davi Casale Aragon, Gleice Clemente, Maria Teresa Terreri, Claudio Arnaldo Len, Rozana Gasparello de Almeida, Marta Cristine Felix Rodrigues, Flavio Sztajnbok, Lia Vineyard Steuer, Matheus Santos França, Clovis Artur Almeida da Silva, Virginia Paes Leme Ferriani, Luciana Martins de Carvalho   +14 more
wiley   +1 more source

Development of an Artificial Intelligence Web Application for Predicting Chemotherapy-Induced Neutropenia in Patients With Non-Small Cell Lung Cancer: A Prospective Study. [PDF]

Cancer Med
Zhang J, Zhai Y, Liu C, Luo M, Liu J, Liu Q, Zhang H, Cai S, Tian Y, Lu L, Zhang L, Yuan H.   +11 more
europepmc   +1 more source

Pediatric Clostridiodes difficile infection with toxic megacolon successfully treated with fecal microbiota transplantation

JPGN Reports, EarlyView.
Abstract The rising incidence of pediatric Clostridioides difficile infection (CDI), particularly in medically complex patients, calls for novel, individualized treatments. While fecal microbiota transplantation (FMT) is well‐described for recurrent CDI, this report describes the first pediatric case of fulminant CDI with toxic megacolon successfully ...
Dana McCarney, Pamela Chen, Jenna Simes, Stacy A. Kahn   +3 more
wiley   +1 more source