Results 41 to 50 of about 21,887 (231)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Research on Flexible Joint Stiffness Test and Trajectory Planning of Space Manipulator

Advances in Mechanical Engineering, 2013
Both Natural Coordinate Formulation describing rigid bodies and Absolute Nodal Coordinate Formulation describing flexible bodies are used to model a flexible manipulator with flexible joint and flexible link.
Yongtai Yang, Jili Rong, Jian Li, Ling Tang   +3 more
doaj   +1 more source

Dynamic characteristics analysis of high speed rotating thin film antenna

Results in Physics, 2022
The thin-film antenna is in a state of high-speed rotation in space, and studying the influence of its structure size on its vibration characteristics can avoid the occurrence of resonance.
Yao Feng, Jimei Wu, Mingyue Shao
doaj   +1 more source

Arbitrary-Lagrangian-Eulerian One-Step WENO Finite Volume Schemes on Unstructured Triangular Meshes

, 2013
In this article we present a new class of high order accurate Arbitrary-Eulerian-Lagrangian (ALE) one-step WENO finite volume schemes for solving nonlinear hyperbolic systems of conservation laws on moving two dimensional unstructured triangular meshes ...
Boscheri, Walter, Dumbser, Michael
core   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Vibration analysis of elevator traveling cable by ANCF considering internal damping

Mechanical Engineering Journal
Traveling cables are important components for elevators that transmit electricity and control command to elevator car. In recent years, as buildings have become taller, traveling cables have also become longer.
Takayoshi KAMADA, Yuki FUKAYAMA, Kazuhiro TANAKA, Tetsu OGAWA, Tomohiro SHIKI, Taku YOSHIDA   +5 more
doaj   +1 more source

Automation of Surgical Workflow Recognition: Unveiling the Surgical Instrument Kinematics that Underly Robot‐Assisted Prostatectomy Procedures

Advanced Intelligent Discovery, EarlyView.
Automated procedural analysis is recognized as one of the major game changers for robotic surgery. Meaning digital analysis needs to replace the manual assessments that set todays standard. Mechanical robotic‐instrument tracking enables the derivation of quantitative kinematic metrics that support behavior‐based workflow segmentation into distinct ...
Kateryna Pirkovets, Matthias N. van Oosterom, Vera A. Ottens, Henk G. van der Poel, Fijs W. B. van Leeuwen   +4 more
wiley   +1 more source

Trajectory planning with residual vibration suppression for space manipulator based on particle swarm optimization algorithm

Advances in Mechanical Engineering, 2017
Space manipulator suffers from vibration problems mainly due to the flexibility of joints and links in a microgravity environment. This article presents a new optimization method of trajectory planning with minimum residual vibration for space ...
Pengfei Xin, Jili Rong, Yongtai Yang, Dalin Xiang, Yang Xiang   +4 more
doaj   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Comparison of Detailed Belt - Cylinder Interaction Model with Classical Belt Friction Formula

Journal of Mechanical Engineering, 2019
This paper deals with a comparison of the classical belt friction formula, also called Euler-Eytelwein equation, with a detailed belt-cylinder interaction model. The belt friction is a typical pedagogical problem where the usage of equilibrium conditions
Bulín Radek, Hajžman Michal
doaj   +1 more source