Results 21 to 30 of about 435 (219)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
مدي شرعية السلطة التقديرية للرقابة الدستورية في حالة الاغفال التشريعي [PDF]
Al-Maǧallah Al-Qānūniyyaẗ, 2020 إذا کانت السلطة التشريعية تتمتع بسلطة تقديرية واسعه في ممارسة اختصاصاتها التشريعية، الا ان هذه السلطة کغيرها من السلطات، ليست سلطة مطلقة او سلطة تحکمية لا قيد عليها، ولکنها سلطة مقيدة، تخضع للعديد من الضوابط والقيود التي يتعين الالتزام بها في تشريعاتها ...
فواز محمد صقر الخرينج
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
EIRP Proceedings, 2020 The absence of the prosecutor when his participation is compulsory is sanctioned with the absolute nullity of all the procedural acts conducted without his involvement.
Sandra Gradinaru
doaj
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
ENFORCEMENT OF THE RIGHT OF DEFENSE IN THE CRIMINAL TRIAL [PDF]
Challenges of the Knowledge Society, 2019 One of the fundamental principles of the criminal trial is the principle of enforcing the right of defense, being not only an expression of the rule of law, but also a necessary condition for the efficient course of justice.
Alina-Marilena ŢUCĂ
doaj
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Revista Vasca de Administración Pública, 2013 This work undertakes the study of the damages inflicted by acts of the Administrations on rights and freedoms which can be redressed by means of constitutional complaint from a documentary corpus up to now poorly utilised by the academic literature: the ...
Alejandra Boto Álvarez
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng +4 more
wiley +1 more source