Results 51 to 60 of about 9,755 (281)

Delayed Foreign Body Reaction Caused by Bioabsorbable Plates Used for Maxillofacial Fractures

Archives of Plastic Surgery, 2016
Background Bioabsorbable plates and screws are commonly used to reduce maxillofacial bones, particularly in pediatric patients because they degrade completely without complications after bone healing.
Hong Bae Jeon, Dong Hee Kang, Ja Hea Gu, Sang Ah Oh   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Process Mechanics and Surface Integrity Induced by Dry and Cryogenic Machining of AZ31B-O Magnesium Alloy [PDF]

, 2013
The corrosion resistance of magnesium alloys depends mainly on its surface integrity. Previous experimental studies have shown that machining can induces small (nano-scale) grain size, compressive residual stresses and basal plane crystallographic ...
Fromentin, G., GERMAIN, Guénaël, Germain, G., Batista, A.C., POULACHON, Gerard, G. Germain, BATISTA, Antonio, G. Poulachon, ROSSI, FREDERIC, Outeiro, J.C., OUTEIRO, José, G. Fromentin, FROMENTIN, Guillaume, A.C. Batista, F. Rossi, Poulachon, G., Rossi, F., MARTINS DO OUTEIRO, Jose Carlos, J.C. Outeiro   +18 more
core   +1 more source

Two-Year Follow-up on the Use of Absorbable Mesh Plates in the Treatment of Medial Orbital Wall Fractures

Archives of Plastic Surgery, 2013
Background Absorbable materials offer many advantages in the reconstruction of orbital walls; however, the possibility of postoperative enophthalmos after complete absorption cannot be excluded.
Jae-Pil You, Deok-Woo Kim, Byung-Joon Jeon, Seong-Ho Jeong, Seung-Kyu Han, Eun-Sang Dhong, Woo-Kyung Kim   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Residual Stresses Induced by Dry and Cryogenic Cooling during Machining of AZ31B Magnesium Alloy [PDF]

, 2014
The major challenge of the Mg alloys has been their unsatisfactory corrosion resistance, which can be enhanced by improving the surface integrity. Cryogenic machining, where liquid nitrogen was used during machining, has been reported to improve the ...
MARQUES, Maria José, OUTEIRO, José, BATISTA, A.C., MARQUES, M.J., Batista, A. C., BATISTA, Antonio, MARTINS DO OUTEIRO, Jose Carlos   +6 more
core  

Refixation of osteochondral fragments using absorbable implants. First results of a retrospective study

, 2003
An osteochondral lesion in a weight bearing joint causes therapeutic problems. Surgical therapy focuses on the restoration of the articular surface, unlimited motion of the joint and prevention of cartilaginous degeneration.
Dumont, C., Sturmer, K. M., Vosshenrich, R., Fuchs, M.   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Absorbable Biosynthetic Scaffolds in Place of Silicone for Breast Reconstruction: A 9-Year Experience with 53 Patients

Plastic and Reconstructive Surgery, Global Open
Background:. Few series report on using fat grafting as the primary form of breast reconstruction. A 9-year experience with absorbable biosynthetic scaffolds, used in place of silicone implants, for breast reconstruction is reviewed. Methods:. A clinical
Robert D. Rehnke, MD, John M. Clarke, MD, Aaron J. Goodrum, MD, Stephen F. Badylak, DVM, PhD, MD   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source