Results 101 to 110 of about 409,007 (252)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Optimal active vibration absorber: Design and experimental results [PDF]

An optimal active vibration absorber can provide guaranteed closed-loop stability and control for large flexible space structures with collocated sensors/actuators.
Juang, Jer-Nan, Lee-Glauser, Gina, Sulla, Jeffrey L.   +2 more
core   +1 more source

A Theoretical-Experimental Comparison of an Improved Ammonia-Water Bubble Absorber by Means of a Helical Static Mixer

Energies, 2017
The heat transfer in double pipe heat exchangers is very poor. This complicates its application in absorption cooling systems, however, the implementation of simple passive techniques should help to increase the heat and mass transfer mainly in the ...
Jesús Cerezo, Roberto Best, Jorge Jesús Chan, Rosenberg J. Romero, Jorge I. Hernandez, Fernando Lara   +5 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

The Effects of Gravity on the Response of Centrifugal Pendulum Vibration Absorbers [PDF]

, 2021
Darryl Tchokogoué, Ming Mu, Brian F. Feeny, Bruce Geist, Steven W. Shaw   +4 more
openalex   +1 more source

The Heavy Element Enrichment of Lyman alpha Clouds in the Virgo Supercluster

, 2002
Using high S/N STIS echelle spectra (FWHM=7 km/s) of 3C 273, we constrain the metallicities of two Lya clouds in the vicinity of the Virgo cluster. We detect C II, Si II, and Si III absorption lines in the Lya absorber at z = 0.00530.
A. C. Danks, Arnaud M., B. E. Woodgate, Binggeli B., C. L. Joseph, C. W. Bowers, D. Lindler, E. B. Jenkins, G. M. Williger, Gibson B. K., Kerr F. J., M. E. Kaiser, Matsumoto H., R. Dave, R. F. Green, R. J. Weymann, Read M. A., S. R. Heap, Schmutzler T., T. M. Tripp, T. R. Gull   +20 more
core   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

All-Metal Metamaterial-Based Sensor with Novel Geometry and Enhanced Sensing Capability at Terahertz Frequency

Sensors
This research proposes an all-metal metamaterial-based absorber with a novel geometry capable of refractive index sensing in the terahertz (THz) range.
Sagnik Banerjee, Ishani Ghosh, Carlo Santini, Fabio Mangini, Rocco Citroni, Fabrizio Frezza   +5 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source