Results 81 to 90 of about 112,410 (304)

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The role of nanoparticle inks in determining the performance of solution processed Cu2ZnSn(S,Se)4thin film solar cells [PDF]

, 2016
Cu2ZnSnS4 (CZTS) nanoparticle inks synthesized by the injection of metal precursors into a hot surfactant offer an attractive route to the fabrication of Earth-abundant Cu2ZnSn(S,Se)4 (CZTSSe) thin film photovoltaic absorber layers.
Qu, Yongtao, Zoppi, Guillaume, Yongtao Qu, Beattie, Neil, Guillaume Zoppi, Neil S. Beattie   +5 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Investigation on a Novel Adiabatic Absorber [PDF]

, 2012
Hot water supplies account for approximately 30% of energy consumption in residential sectors of Japan; it is therefore important that the energy efficiency of water heaters be improved.
Dang, Chaobin, Hihara, Eiji, Okamoto, Hiroaki   +2 more
core  

Passively mode-locked diode-pumped surface-emitting semiconductor laser

, 2000
A surface-emitting semiconductor laser has been passively mode locked in an external cavity incorporating a semiconductor saturable absorber mirror. The gain medium consists of a stack of 12 InGaAs-GaAs strained quantum wells, grown above a Bragg mirror ...
Tropper, A.C., Morier-Genoud, F., F. Morier-Genoud, J. S. Roberts, Roberts, J.S., Garnache, A., A. C. Tropper, Keller, U., Paschotta, R., A. Garnache, Oesterle, U., S. Dhanjal, U. Oesterle, Dhanjal, S., Häring, R., R. Häring, R. Paschotta, S. Hoogland, U. Keller, Hoogland, S.   +19 more
core   +1 more source

Application of Metamaterial in Perfect Absorber

Cailiao gongcheng, 2016
Electromagnetic response of metamaterials is not only determined by its component materials but also the microstructure and arrangements of its resonant elements. The perfect absorber prepared by metamaterial (PMA) can realize 100% absorption in specific
ZHANG Yong, ZHANG Bin-zhen, DUAN Jun-ping, WANG Wan-jun   +3 more
doaj   +1 more source

Quasi-n-absorbing and semi-n-absorbing preradicals

Hacettepe Journal of Mathematics and Statistics, 2019
Summary: The aim of this paper is to introduce the notions of quasi-\(n\)-absorbing preradicals and of semi-\(n\)-absorbing preradicals. These notions are inspired by applying the concept of \(n\)-absorbing preradicals to semiprime preradicals. Also, we study the concepts of quasi-\(n\)-absorbing submodules and of semi-\(n\)-absorbing submodules and ...
MOSTAFANASAB, Hojjat, YOUSEFİAN DARANİ, Ahmad   +1 more
openaire   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source