Results 101 to 110 of about 237,588 (284)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Equivalent Conditions for Irreducibility of Discrete Time Markov Chains [PDF]
We consider discrete time Markov chains on general state space. It is shown that a certain property referred to here as nondecomposability is equivalent to irreducibility, and that a Markov chain with invariant distribution is irreducible if and only if ...
Cuong Le Van, John Stachurski
core
Reconstruction of discrete sets from two absorbed projections: an algorithm
Electronic Notes in Discrete Mathematics, 2003 Abstract Two left and right horizontal absorbed projections along a single direction uniquely determine a row of a binary matrix. After proving this result we give a polynomial time algorithm which reconstructs such a row and we analyze its performances by determining the worst case complexity.
BARCUCCI, ELENA +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Normal systems over ANR’s, rigid embeddings and nonseparable absorbing sets [PDF]
Acta Mathematica Sinica, English Series, 2012 26 ...
openaire +3 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Absorbing Sets in Coalitional Systems
, 2001 The purpose of this paper is twofold: First, to present an approach and a solution for analyzing the stability of coalition structures: We define a coalitional system (a set and a binary relation on that set) that explains the transitions between coalition structures and we propose to solve these systems using the absorbing sets solution for abstract ...
Olaizola Ortega, María Norma +2 more
openaire +1 more source
Asymptotic Absorbing Set Enumerators for Irregular LDPC Code Ensembles
, 2020 International Zurich Seminar on Information and Communication (IZS 2020 ...
Ben Yacoub, Emna, Liva, Gianluigi
openaire +3 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source