Results 91 to 100 of about 237,588 (284)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Exchange of indivisible goods and indifferences: the Top Trading Absorbing Sets mechanisms [PDF]
There is a wide range of economic problems involving the exchange of indivisible goods without monetary transfers, starting from the housing market model of the seminal paper of Shapley and Scarf [10] and including other problems like the kidney exchange
ALCALDE-UNZU, Jorge, MOLIS, Elena
core
On Soft Near-Prime Int-Ideals and Soft 1-Absorbing Prime Int-Ideals With Applications
Journal of MathematicsIn this study, we aimed to introduce two different generalizations of the soft prime int-ideal and clarify the relationships between the soft prime int-ideal and the substructures of a ring. First, we explored new algebraic features of the soft prime int-
İbrahim Halil Kanat, Filiz Çıtak
doaj +1 more source
Infinite kernel perfect digraphs
AKCE International Journal of Graphs and Combinatorics, 2017 Let be a digraph, possibly infinite, V() and A() will denote the sets of vertices and arcs of , respectively. A subset of V() is said to be a kernel if it is both independent (a vertex in has no successor in ) and absorbing (a vertex not in has a ...
Rocío Sánchez-López
doaj +1 more source
An absorbing set for the Chialvo map
Communications in Nonlinear Science and Numerical SimulationThe classical Chialvo model, introduced in 1995, is one of the most important models that describe single neuron dynamics. In order to conduct effective numerical analysis of this model, it is necessary to obtain a rigorous estimate for the maximal bounded invariant set.
Paweł Pilarczyk, Grzegorz Graff
openaire +3 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Scaling behavior of the contact process in networks with long-range connections
, 2009 We present simulation results for the contact process on regular, cubic networks that are composed of a one-dimensional lattice and a set of long edges with unbounded length.
G. Ódor +6 more
core +1 more source
Estimation of aerosol and cloud radiative heating rate in the tropical stratosphere using a radiative kernel method [PDF]
Geoscientific Model DevelopmentA layer of aerosols has been identified in the upper troposphere and lower stratosphere above the Asian summer monsoon (ASM) region, typically referred to as the Asian Tropopause Aerosol Layer (ATAL).
J. Gao +6 more
doaj +1 more source