Results 51 to 60 of about 109,366 (301)
Systems, 2022 Numerous researchers have investigated the concept of green absorptive capacity, but relatively few studies have been performed on its antecedents. The objective of the present research was to develop and empirically test a theoretical model, which ...
Burcu Ozgul
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Journal of Innovation & Knowledge, 2023 The purpose of this study is to explore the role of potential and realized absorptive capacity on project success through both the mediating roles of strategic agility and the moderating role of project complexity.
Mário Nuno Mata +2 more
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Investigating Absorptive Capacity Strategies Via Simulation [PDF]
ECMS 2012 Proceedings edited by: K. G. Troitzsch, M. Moehring, U. Lotzmann, 2012 Absorptive capacity, defined as the organizational capability to identify, absorb and exploit knowledge, is one of the most discussed topics in the management literature. Yet, its complex nature makes it almost impossible to empirically test it. This paper develops SimAC, an agent-based simulation tool that enables studying and comparing different ...
Aversa, P., Ihrig, M.
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Redefining the Relationship between Intellectual Capital and Innovation: The Mediating Role of Absorptive Capacity [PDF]
BAR: Brazilian Administration Review, 2016 The objective of this study is to analyze the relationship between absorptive capacity, intellectual capital and innovation. The main purpose of this research is to demonstrate that absorptive capacity can leverage the relation between intellectual ...
Alessandra Cassol +2 more
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