Results 151 to 160 of about 21,169,644 (268)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The Landscape on Access to Maternal and Child Health Services During the COVID-19 Pandemic in South Africa: A Scoping Review. [PDF]

Interdiscip Perspect Infect Dis
Chikuse D, Badacho AS, Uwimana-Nicol J, Hendricks L, Nyasulu JCY.   +4 more
europepmc   +1 more source

Imposing Observation-Varying Equality Constraints Using Generalised Restricted Least Squares [PDF]

Linear equality restrictions derived from economic theory are frequently observation-varying. Except in special cases, Restricted Least Squares (RLS) cannot be used to impose such restrictions without either underconstraining or overconstraining the ...
Dr Alicia Rambaldi, Dr Chris O'Donnell, Howard E.Doran   +2 more
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Neural mechanisms of acupuncture in amnestic mild cognitive impairment: a protocol for an fMRI-based systematic review and meta-analysis. [PDF]

Front Neurol
Zhu T, Yang D, Quan F, Chen Y, Cui J.
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Non-pharmacological interventions for managing acute pain and delirium in hospitalized older patients: a systematic review. [PDF]

BMC Geriatr
Prandeh Afshar P, Ali ESA, Dehghan F, Dehghan M.   +3 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

ABSTRACTS

Wildlife Biology, 1991
J. G. Morgan, H. A. Pereira, T. Sukiennicki, J. K. Spitznagel, J. W. Larrick, D. R. Forsdyke, S. Blum, D. P. Sideris, R. E. Forsdyke, H. Yu, E. Carstens, T. Hattori, Y. Yamamura, Y. Ohmoto, T. Nishida, K. Takatsuki, P. Tekamp-Olson, C. Gallegos, D. Bauer, J. McClain, B. Sherry, M. Fabre, S. van Deventer, A. Cerami, M. Napolitano, W. S. Modi, V. H. Seuanez, S. J. Cevario, W. J. Leonard, T. Schall, K. Toy, D. V. Goeddel, C. A. Hébert, F. W. Luscinskas, J-M. Kiely, E. A. Luis, W. C. Darbonne, G. T. Bennett, C. C. Liu, M. S. Obin, M. A. Gimbrone, J. B. Baker, K. A. Brown, F. Le Roy, G. Noble, K. Bacon, R. Camp, A. Vora, D. C. Dumonde, P. D. Collins, P. J. Jose, T. J. Williams, M. Rampart, J. Van Damme, W. Fiers, A. G. Herman, O. Pos, M. F. Geertsma, A. Stevenhagen, P. N. Nibbering, R. van Furth, K. B. Bacon, R. D. R. Camp, A. B. Millar, A. Meager, S. J. G. Semple, G. A. W. Rook, M. Stein, S. Gordon, K. Morrison, D. B. Jones, E. Y. Jones, D. I. Stuart, N. P. C. Walker, M. K. Thomsen, C. G. Larsen, K. Thestrup-Pedersen, M. Kristensen, K. Paludan, B. Deleuren, K. Kragballe, K. Matsushima, J. M. Wang, G. Taraboletti, A. Mantovani, A. Sica, K. Zachariae, I. Colditz, M. Baggiolini, F. Q. Cunha, B. B. Lorenzetti, S. H. Ferreira, T. J. Standiford, S. L. Kunkel, R. M. Strieter, S. W. Chensue, J. Westwick, K. Kasahara, R. A. Ribeiro, L. H. Faccioli, G. E. P. Souza, C. A. Flores, K. Kasahara, D. G. Quinn, A. Haslberger, C. Foster, M. Ceska, N. Ryder, E. Kugler, I. Lindley, J. N. W. N. Barker, M. L. Jones, R. S. Mitra, C. Swenson, K. Johnson, J. C. Fantone, V. M. Dixit, B. J. Nickoloff, C. Lam, L. Klein, A. Tuschil, J. Y. Shyy, Y. S. Li, D. W. Massop, J. F. Cornhill, P. E. Kolattukudy, R. Pleass, Z. Brown, L. Fairbanks, R. Thomas   +129 more
openaire   +1 more source