Results 91 to 100 of about 10,189,806 (382)

Higher-order Representation and Reasoning for Automated Ontology Evolution [PDF]

, 2010
: The GALILEO system aims at realising automated ontology evolution. This is necessary to enable intelligent agents to manipulate their own knowledge autonomously and thus reason and communicate effectively in open, dynamic digital environments ...
Bundy, Alan, Chan, M., Lehmann, J.
core  

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

scClassify: sample size estimation and multiscale classification of cells using single and multiple reference

Molecular Systems Biology, 2020
Automated cell type identification is a key computational challenge in single‐cell RNA‐sequencing (scRNA‐seq) data. To capitalise on the large collection of well‐annotated scRNA‐seq datasets, we developed scClassify, a multiscale classification framework
Yingxin Lin, Yue Cao, Hani Jieun Kim, Agus Salim, Terence P Speed, David M Lin, Pengyi Yang, Jean Yee Hwa Yang   +7 more
doaj   +1 more source

Improving a data-acquisition software system with abstract data type components [PDF]

data types and object-oriented design are active research areas in computer science and software engineering. Much of the interest is aimed at new software development.
Howard, S. D.
core   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

scCTS: identifying the cell type-specific marker genes from population-level single-cell RNA-seq

Genome Biology
Single-cell RNA-sequencing (scRNA-seq) provides gene expression profiles of individual cells from complex samples, facilitating the detection of cell type-specific marker genes.
Luxiao Chen, Zhenxing Guo, Tao Deng, Hao Wu   +3 more
doaj   +1 more source

Lower Limits on $\mu \to e \gamma$ from new Measurements on $U_{e3}$

, 2012
New data on the lepton mixing angle $\theta_{13}$ imply that the $e\mu$ element of the matrix $m_\nu m_\nu^\dagger$, where $m_\nu$ is the neutrino Majorana mass matrix, cannot vanish. This implies a lower limit on lepton flavor violating processes in the
Chakrabortty, Joydeep, Ghosh, Pradipta, Rodejohann, Werner   +2 more
core   +2 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

In-situ calibration of Ishii-type multicomponent borehole strainmeters deployed in southwest Japan

Earth, Planets and Space
A multicomponent borehole strainmeter is a highly sensitive geodetic instrument capable of detecting small tectonic faulting such as slow slip events in subduction zones. However, in-situ calibration and thorough validation of the calibration results are
Norio Matsumoto, Osamu Kamigaichi, Suguru Yabe   +2 more
doaj   +1 more source

Abstracted navigational actions for improved hypermedia navigation and maintainance. [PDF]

This paper discusses the MESH framework, which proposes a fully object-oriented approach to hypermedia. Object-oriented abstractions are not only applied to the conceptual data model, but also to the navigation paradigm.
Lemahieu, Wilfried
core