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Type VI Secretion Effectors: Methodologies and Biology [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 The type VI secretion system (T6SS) is a nanomachine deployed by many Gram-negative bacteria as a weapon against eukaryotic hosts or prokaryotic competitors.
Yun-Wei Lien +3 more
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The integrative biology of type 2 diabetes [PDF]
Nature, 2019 Obesity and type 2 diabetes are the most frequent metabolic disorders, but their causes remain largely unclear. Insulin resistance, the common underlying abnormality, results from imbalance between energy intake and expenditure favouring nutrient-storage pathways, which evolved to maximize energy utilization and preserve adequate substrate supply to ...
Michael, Roden, Gerald I, Shulman
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Guarding the frontiers: the biology of type III interferons [PDF]
Nature Immunology, 2015 Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect them against the frequent viral attacks that are typical for barrier tissues. IFN-λs thereby help to maintain healthy mucosal surfaces through immune protection, without
Andreas Wack +2 more
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Macroscopic Quantum-Type Potentials in Theoretical Systems Biology [PDF]
Cells, 2013 We review in this paper the use of the theory of scale relativity and fractal space-time as a tool particularly well adapted to the possible development of a future genuine systems theoretical biology.
Laurent Nottale
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Antibiotics targeting bacterial protein synthesis reduce the lytic activity of bacteriophages
Virus Research, 2022 Combination therapy of bacteriophages and antibiotics requires careful selection of specific antibiotics as it is crucial towards determining the success of phage therapy to treat multiple drug-resistant bacterial infections.
Medhavi Vashisth +5 more
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The biology, function, and biomedical applications of exosomes
Science, 2020 Clinical uses of cellular communication Exosomes are a type of extracellular vesicle that contain constituents (protein, DNA, and RNA) of the cells that secrete them.
R. Kalluri, Valerie S. LeBleu
semanticscholar +1 more source
Scientific Reports, 2023 A rod-shaped, motile, Gram-negative bacterial strain named DM-R-R2A-13T was isolated from the plant Cannabis sativa L. ‘Cheungsam’. The phylogenetic analysis of the 16S rRNA gene sequence revealed that strain DM-R-R2A-13T belongs to the family ...
Doeun Jeon +8 more
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mSystems, 2019 The release of synthetic chemical pollutants in the environment is posing serious health risks. Enzymes, including oxygenases, play a crucial role in xenobiotic degradation. In the present study, we employed a functional metagenomics approach to overcome
Chandni Sidhu +3 more
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Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Despite clear differences in female and male immunity that may contribute to variations in response to infections and predisposition to cancer and autoimmunity, the exact mechanisms that drive this stark contrast remain insufficiently ...
Sarthak Gupta +24 more
semanticscholar +1 more source
Bone Turnover Markers: Basic Biology to Clinical Applications
Endocrine reviews, 2022 Bone turnover markers (BTMs) are used widely, in both research and clinical practice. In the last 20 years, much experience has been gained in measurement and interpretation of these markers, which include commonly used bone formation markers (bone ...
M. Schini +4 more
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