Results 181 to 190 of about 6,254,795 (351)

SDePER: a hybrid machine learning and regression method for cell-type deconvolution of spatial barcoding-based transcriptomic data

Genome Biology
Spatial barcoding-based transcriptomic (ST) data require deconvolution for cellular-level downstream analysis. Here we present SDePER, a hybrid machine learning and regression method to deconvolve ST data using reference single-cell RNA sequencing (scRNA-
Yunqing Liu, Ningshan Li, Ji Qi, Gang Xu, Jiayi Zhao, Nating Wang, Xiayuan Huang, Wenhao Jiang, Huanhuan Wei, Aurélien Justet, Taylor S. Adams, Robert Homer, Amei Amei, Ivan O. Rosas, Naftali Kaminski, Zuoheng Wang, Xiting Yan   +16 more
doaj   +1 more source

Abstract data type support in Prolog and its relation to parallelism [PDF]

, 1994
Isambo Karali, C. Halatsis
openalex   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Benchmarking cell type annotation methods for 10x Xenium spatial transcriptomics data

BMC Bioinformatics
Background Imaging-based spatial transcriptomics technologies allow us to explore spatial gene expression profiles at the cellular level. Cell type annotation of imaging-based spatial data is challenging due to the small gene panel, but it is a crucial ...
Jinming Cheng, Xinyi Jin, Gordon K. Smyth, Yunshun Chen   +3 more
doaj   +1 more source

Observability Concepts in Abstract Data Type Specification, 30 Years Later [PDF]

, 2008
A. Joyal, A. Kurz, C.B. Jones, D. Sannella, D. Sannella, D. Sannella, D. Sannella, H. Ehrig, J.A. Goguen, J.A. Goguen, J.J.M.M. Rutten, M. Bidoit, M. Bidoit, M. Bidoit, M. Wand, M. Wirsing, R. Allen, S. Lasota, S. Lasota, V. Giarratana   +19 more
core   +2 more sources

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Practical ultra‐reliability for abstract data types [PDF]

, 2007
Borislav Nikolik, Dick Hamlet
openalex   +1 more source

Deconvolution from bulk gene expression by leveraging sample-wise and gene-wise similarities and single-cell RNA-seq data

BMC Genomics
Background The widely adopted bulk RNA-seq measures the gene expression average of cells, masking cell type heterogeneity, which confounds downstream analyses.
Chenqi Wang, Yifan Lin, Shuchao Li, Jinting Guan   +3 more
doaj   +1 more source

Poster : Blockchain abstract data type

, 2019
This paper is the first to specify blockchains as a composition of abstract data types all together with a hierarchy of consistency criteria that formally characterizes the histories admissible for distributed programs that use them. The paper presents as well some results on implementability of the presented abstractions and a mapping of ...
Anceaume, Emmanuelle, del Pozzo, Antonella, Ludinard, Romaric, Potop-Butucaru, Maria, Tucci-Piergiovanni, Sara   +4 more
openaire   +2 more sources