Results 81 to 90 of about 5,183,162 (349)

Brain Cell Type Specific Gene Expression and Co-expression Network Architectures

Scientific Reports, 2018
Elucidating brain cell type specific gene expression patterns is critical towards a better understanding of how cell-cell communications may influence brain functions and dysfunctions.
Andrew T. McKenzie, Minghui Wang, Mads E. Hauberg, John F. Fullard, Alexey Kozlenkov, Alexandra Keenan, Yasmin L. Hurd, Stella Dracheva, Patrizia Casaccia, Panos Roussos, Bin Zhang   +10 more
doaj   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Algebraic implementation of abstract data types

Theoretical Computer Science, 1982
AbstractStarting with a review of the theory of algebraic specifications in the sense of the ADJ-group a new theory for algebraic implementations of abstract data types is presented.While main concepts of this new theory were given already at several conferences this paper provides the full theory of algebraic implementations developed in Berlin except
Hans-Jörg Kreowski, Peter Padawitz, Hartmut Ehrig, Bernd Mahr   +3 more
openaire   +2 more sources

PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data

Database J. Biol. Databases Curation, 2019
Single-cell RNA sequencing is an increasingly used method to measure gene expression at the single cell level and build cell-type atlases of tissues. Hundreds of single-cell sequencing datasets have already been published. However, studies are frequently
Oscar Franzén, L. Gan, J. Björkegren
semanticscholar   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology

Bioinform., 2019
Motivation The composition and density of immune cells in the tumor microenvironment (TME) profoundly influence tumor progression and success of anti-cancer therapies.
G. Sturm, F. Finotello, F. Petitprez, J. Zhang, J. Baumbach, W. Fridman, M. List, T. Aneichyk   +7 more
semanticscholar   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Nondeterminism in abstract data types [PDF]

, 1981
A nondeterministic operation is characterized by the fact that its application to a given set of parameters can yield any one of several possible outcomes. This paper discusses ways to specify, implement, and reason about nondeterministic operations in the context of abstract (algebraic) data types.
openaire   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Exterior design of main houses with regard to building layout in rural house compounds in special preservation areas for historic landscape

Japan Architectural Review
Asuka village in Nara Prefecture has been designated as one of the “Special Conservation Areas for Historic Landscape” since the 1960s and is known for its richness in historic remains from the Asuka period.
Naohiko Yamamoto, Kazuhiro Hirao, Tetsuya Yoshida, Chie Murosaki   +3 more
doaj   +1 more source