Results 81 to 90 of about 761,584 (320)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Imperial strategy of cancer cells through mitochondrial transfer

Molecular Oncology, EarlyView.
Cangkrama et al. demonstrated that cancer cells donate their mitochondria to fibroblasts through mitochondrial transfer, reprogramming them into ‘MitoCAF’. Likewise, our group has identified mitochondrial transfer from cancer cells to tumor infiltrating lymphocytes, resulting in mitochondrial ‘hijack’ and impaired antitumor immunity.
Takamasa Ishino, Yosuke Togashi
wiley   +1 more source

Improving Abstraction in Text Summarization

, 2018
ive text summarization aims to shorten long text documents into a human readable form that contains the most important facts from the original document.
Kryściński, Wojciech, Paulus, Romain, Socher, Richard, Xiong, Caiming   +3 more
core   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Starting points and artistic premises in abstraction by artist Wassily Kandinsky as an entrance for teaching the principles and rules of abstraction and enriching the art work painting for art education students

Journal of Architecture, Art & Humanistic Science
The main idea of this research was inspired from a desire to clarify some of artist Wassily Kandinsky's Starting points and artistic premises in abstraction and to benefit from them as an entrance for teaching the principles of abstract painting and ...
Dr. Amal Mahrous Abdel Gani
doaj   +1 more source

Lazy Abstraction-Based Controller Synthesis

, 2019
We present lazy abstraction-based controller synthesis (ABCS) for continuous-time nonlinear dynamical systems against reach-avoid and safety specifications.
A Borri, A Girard, A Girard, A Girard, D Beyer, D Beyer, E Clarke, F Cassez, F Herbreteau, G Pola, G Reissig, IM Mitchell, K Mallik, L Alfaro de, L Fribourg, L Grüne, O Maler, P Nilsson, P Nilsson, P Tabuada, TA Henzinger, TA Henzinger   +21 more
core   +1 more source

Sensing the Present: “Conceptual Art of the Senses”

Text Matters, 2017
After Rachel E. Burke briefly introduces the essays presented with a focus on our contemporary relationship to modern subjectivity, Mieke Bal will make the case for the sense of presentness on an affective and sensuous level in Munch’s paintings and ...
Mieke Bal, Rachel E. Burke
doaj   +1 more source

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

Neighbourhood Abstraction in GROOVE - Tool Paper [PDF]

, 2010
In this paper we discuss the implementation of neighbourhood graph abstraction in the GROOVE tool set. Important classes of graph grammars may have unbounded state spaces and therefore cannot be verified with traditional model checking techniques.
Rensink, Arend, Zambon, Eduardo
core   +1 more source

Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

Aging and Cancer, EarlyView.
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth, Dylan D. Thomas, Remi Nohoesu, Angisha Basnet, F. Heath Damron, Mary Garland‐Kledzik, Emel Sen Kilic, Tracy W. Liu   +7 more
wiley   +1 more source