Results 91 to 100 of about 2,931,284 (276)
, 2015 The solar photospheric abundance of oxygen is still a matter of debate. For about ten years some determinations have favoured a low oxygen abundance which is at variance with the value inferred by helioseismology.
Bonifacio, P. +7 more
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Evaluation of climate change scenarios based on aquatic food web modelling [PDF]
, 2008 In the years 2004 and 2005 we collected samples of phytoplankton, zooplankton and macroinvertebrates in an artificial small pond in Budapest. We set up a simulation model predicting the abundance of the cyclopoids, Eudiaptomus zachariasi and Ischnura ...
Hufnagel, Levente +3 more
core
Project VeSElkA: Search for vertical stratification of element abundances in HD157087
, 2018 The new spectropolarimetric spectra of HD157087 obtained recently with ESPaDOnS at CFHT are analysed to verify the nature of this object. The fundamental stellar parameters $T_{\rm eff}$ = 8882 K, $\log{g}$=3.57 have been obtained for HD157087 from the ...
Khalack, Viktor
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Početnosť a rozšírenie kuvika obyčajného (Athene noctua) v Rimavskej kotline (južné Slovensko) / The abundance and distribution of Little Owl (Athene noctua) in Rimavská kotlina Basin (S Slovakia) [PDF]
Tichodroma, 2018 The abundance and distribution of Little Owl was monitored in Rimavská kotlina Basin (central Slovakia) in the years 2015–2017 using visual observations, recording of spontaneous calls and playback of male territorial calls.
Monika GÁLFFYOVÁ
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source