Results 191 to 200 of about 3,683,011 (357)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Soil nematode abundance and functional group composition at a global scale

Nature, 2019
J. Hoogen, S. Geisen, D. Routh, H. Ferris, W. Traunspurger, D. Wardle, R. Goede, Byron J. Adams, W. Ahmad, W. Andriuzzi, R. Bardgett, M. Bonkowski, R. Campos-Herrera, J. Cares, T. Caruso, Larissa de Brito Caixeta, Xiaoyun Chen, Sofia dos, Santos da Rocha Costa, R. Creamer, J. M. D. C. Castro, M. Dam, D. Djigal, M. Escuer, Bryan S. Griffiths, C. Gutiérrez, Karin Hohberg, D. Kalinkina, P. Kardol, Alan Kergunteuil, G. Korthals, Valentyna Krashevska, A. Kudrin, Qi Li, W. Liang, M. Magilton, M. Marais, José Antonio Rodríguez Martín, E. Matveeva, E. Mayad, C. Mulder, P. Mullin, R. Neilson, Duong Nguyen, Uffe N. Nielsen, H. Okada, Juan Emilio, Palomares Rius, K. Pan, V. Peneva, L. Pellissier, Julio Carlos Pereira da Silva, Camille Pitteloud, Thomas O. Powers, K. Powers, C. Quist, S. Rasmann, S. S. Moreno, S. Scheu, H. Setälä, A. Sushchuk, A. Tiunov, J. Trap, W. V. D. Putten, Mette Vestergård, C. Villenave, L. Waeyenberge, Diana H.Wall, R. Wilschut, Daniel G. Wright, Jiue-in Yang, T. Crowther   +71 more
semanticscholar   +1 more source

Foraging Ranges of Insectivorous Bats Shift Relative to Changes in Mosquito Abundance

, 2013
Leroy Gonsalves, Bradley Law, Cameron Webb, Vaughan Monamy   +3 more
openalex   +2 more sources

Effect of Anthropogenic Type and Depth on Microplastic Abundance in Mahakam River Water, Samarinda City

, 2023
Ika Meicahayanti, Putri Intan Permata Sari, Searphin Nugroho, Dwi Ermawati Rahayu, Ibrahim Ibrahim   +4 more
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Irrigation water salinity and N fertilization: Effects on ammonia oxidizer abundance, enzyme activity and cotton growth in a drip irrigated cotton field

, 2016
Min Wei, Huijuan Guo, Wen Zhang, Guangwei Zhou, Lijuan Ma, Jun Ye, Zhenan Hou   +6 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA

Science, 2005
C. Jopling, M. Yi, Alissa M. Lancaster, S. Lemon, P. Sarnow   +4 more
semanticscholar   +1 more source