Results 161 to 170 of about 1,169,779 (313)

Opioid Abuse in Chronic Pain--Misconceptions and Mitigation Strategies.

New England Journal of Medicine, 2016
Dan L. Longo, N. Volkow, A. Mclellan
semanticscholar   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Forensic Perspectives on Child Sexual Abuse Disclosure in Greece: A Retrospective Study. [PDF]

Pediatr Rep
Dimitriou K, Efthymiou V, Fragkou K, Peyron PA, Martrille L, Baccino E, Bacopoulou F, Papadodima S.   +7 more
europepmc   +1 more source

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source

fMRI reveals changes in basal metabolism induced by daily high-density TBS (hdTBS) for five days focally delivered to naïve rats

Brain Stimulation
Hanbing Lu, Qiong Li, Samantha Hoffman, Aidan Carney, Ying Duan, Zilu Ma, Nanyin Zhang, Yihong Yang   +7 more
doaj   +1 more source

Childhood Trauma Across the Schizophrenia Spectrum: A Comparison of Schizotypal Personality Disorder and Schizophrenia. [PDF]

Schizophr Bull
Chan CC, Dolgopolskaia ES, Goldstein KE, Kowalchyk M, Aladin S, Challman KN, Ng S, Reynolds K, Russo D, Kapil-Pair KN, Hollander S, Rice T, Perez-Rodriguez MM, Haznedar MM, McClure MM, Szeszko PR, Hazlett EA.   +16 more
europepmc   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Qualitative insights on help-seeking from older Australian women with lived experience of elder abuse. [PDF]

J Gerontol B Psychol Sci Soc Sci
Brijnath B, Muoio R, Najman J, Marrington S, Clavarino A, McGee TR, Gilbard A.   +6 more
europepmc   +1 more source

Pilot Results of a Handbook: Prevention Skills of Sexual-Abuse for Primary Students

, 2019
Son Van Huynh, Thien-Vu Giang, Hanh My, Huan Thanh Nguyen   +3 more
openalex   +2 more sources

The re-enactment of childhood sexual abuse in maternity care: a qualitative study [PDF]

, 2015
Elsa Montgomery, Catherine Pope, Jane E. Rogers   +2 more
openalex   +1 more source