Results 111 to 120 of about 166,100,578 (284)
A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau
Advanced Science, EarlyView.TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun +12 more
wiley +1 more source
REHABILITATION OF AN INDIVIDUAL, BROUGHT IN AS A SUSPECT OR DEFENDANT
Хабаршы. Заң сериясы, 2018 Rehabilitation should be perceived as the most substantial institution of criminal procedural law, implying compensation of property and elimination of moral harm, as well as the restoration of the rights of an individual to have been ...
Sharipova A.B.
doaj
Revista de Ciências Jurídicas e Sociais da UNIPARWhat does influence the issuance of Preliminary Injunctions (in limine) in Writs of Mandamus within the jurisdiction of Pernambuco's Federal Court?
Renan Francelino Silva +3 more
doaj +1 more source
Advanced Science, EarlyView.Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao +10 more
wiley +1 more source
LEGAL LIABILITY CONDITIONS FOR THE ABUSE OF LAW [PDF]
Challenges of the Knowledge Society, 2014 Knowing that in more and more cases, the only defence of the party whose law or interest has been injured is to invoke the abuse of law, the express interdiction of the abuse of law becomes a need as an answer to the social demand for legality and ...
Emilian CIONGARU
doaj
Advanced Science, EarlyView.Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li +17 more
wiley +1 more source
Civilizar, 2014 The Department of Chocó is a “territory with an incalculable natural, ethnic and cultural wealth” (¿Qué es él Chocó Biogeográfico?, 2013); Prior consultation is a right and a mechanism involving ethnic groups, however, is not effective, or is an ...
Marisela Mena Valencia +1 more
doaj
Al-AdalahThe tension between statutory marriage registration requirements and the socio-religious legitimacy of nikah siri (unregistered marriages) continues to create challenges in the implementation of family law in Indonesia.
Siti Nur Fajriyati +2 more
doaj +1 more source
Advanced Science, EarlyView.An asymmetric sulfonate solvent forms thermally stable interphases and demonstrates non‐flammability, suppressing heat accumulation for safer, high‐performance lithium‐ion batteries. ABSTRACT An asymmetric sulfonate‐based linear solvent, 2,2,2‐trifluoromethyl mesylate (FMS), is designed and used as the primary solvent in liquid electrolytes to enhance ...
Chi‐Yeong Hong +12 more
wiley +1 more source
Artificial Intelligence‐Empowered Single‐Cell Phenotyping for Rapid, Automated Pathogen Diagnostics
Advanced Science, EarlyView.This work presents an integrated diagnostic platform that combines microfluidic single‐cell bacterial detection with artificial intelligence‐driven analysis for rapid antimicrobial susceptibility testing. Single‐cell phenotyping enables assessment of antibiotic response in only a few cell replication cycles, while AI analysis supports precise bacterial
Sabita Khadka +3 more
wiley +1 more source