Results 111 to 120 of about 1,243,573 (351)

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Time for Action: Incidents of Discrimination in Russian Football [PDF]

, 2015
This monitoring report presents the first ever systematic assessment of the problem of racism and discrimination in Russian football. Prepared as a joint undertaking of the Moscow-based SOVA Center for Information and Analysis and the Fare network, it ...

core  

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

Comparative legal analysis of the categories of “abuse of rights” and “abuse of freedom of contract” (fraudulent transaction)

Bulletin of Kharkiv National University of Internal Affairs
In the article, the author conducts a comparative legal analysis of the concepts of “abuse of rights” and “abuse of freedom of contract” within the context of fraudulent transactions in Ukraine.
H. S. Hofeld
doaj   +1 more source

Criminalizing Substance Abuse and Undermining Roe v. Wade: The Tension Between Abortion Doctrine and the Criminalization of Prenatal Substance Abuse

, 2017
woman’s constitutional right to have an abortion. Although other scholars have criticized prenatal substance abuse prosecutions based on various constitutional and public policy arguments, the tension between prenatal substance abuse prosecutions and the
Lewis, Myrisha S.
core  

Why do women not use antenatal services in low and middle income countries? A metasynthesis of qualitative studies [PDF]

, 2013
Background: Almost 50% of women in low & middle income countries (LMIC’s) don’t receive adequate antenatal care. Women’s views can offer important insights into this problem.
A Johnson, AAA Ali, B Amooti-Kaguna, B Simkhada, B Simkhada, C Ronsmans, CA Brown, CF Pretorius, CR Titaley, D Walsh, DG Basani, DS Manandhar, E Stokes, F Grossmann-Kendall, G Carroli, G Thomson, GB Kyomuhendo, GM Mubyazi, GW Pariyo, J Skinner, J Villar, JD Pandian, K Regmi, Karen Daniels, Kenneth Finlayson, L Atuyambe, L Myer, LA Jensen, LK Smith, LTT Trinh, M Dixon-Woods, M Kabir, M Mrisho, M Perkins, M Sandelowski, M Sandelowski, MC Hogan, N Abrahams, N Britten, N Choudhury, O Campbell, P Griffiths, P Pound, R Gcaba, R Ndyomugyenyi, R Pawson, R Pawson, R Tinoco-Ojanguren, RE Rowe, RR Chapman, S Downe, S Downe, S Gruskin, S Lim, S Matsuoka, S Ngomane, S Thaddeus, Soo Downe, T Dowswell, T Kabakian-Khasholian, TAJ Houweling, TS Ravindran, Z Mumtaz   +62 more
core   +3 more sources

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

Abuse of human rights

, 2020
coverage ...
openaire   +1 more source

Disrupting the Path from Childhood Trauma to Juvenile Justice: An Upstream Health and Justice Approach [PDF]

, 2016
A groundbreaking public health study funded by the U.S. Centers for Disease Control and Prevention (CDC) and the Kaiser Foundation found astoundingly high rates of childhood trauma, including experiences like abuse, neglect, parental substance abuse ...
Cannon, Yael, Hsi, Andrew
core   +2 more sources

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source