Results 111 to 120 of about 937,564 (308)

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

open access: yesAdvanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li   +10 more
wiley   +1 more source

Myspace, Yourspace, But Not Theirspace: The Constitutionality of Banning Sex Offenders From Social Networking Sites [PDF]

open access: yes, 2011
In recent years there has been intense public pressure to enact increasingly restrictive and intrusive sex offender laws. The regulation of sex offenders has now moved online, where a growing amount of protected expression and activity occurs. The latest
Wynton, Jasmine S.
core   +1 more source

Abuse of Rights in International Arbitration [PDF]

open access: yes, 2020
Abstract In recent years, international arbitration has become plagued by different forms of substantive and procedural abuse. For example, we have witnessed a rise in cases where parties restructure their investments in an abusive manner by altering one of its features purely to gain access to ICSID arbitration.
openaire   +1 more source

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

open access: yesAdvanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies   +14 more
wiley   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

open access: yesAdvanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang   +8 more
wiley   +1 more source

Зловживання пасивним виборчим правом: теорія та практика [PDF]

open access: yes, 2011
Зловживання правом — суперечливе наукове поняття, майже не досліджене в межах виборчого права, але широко розповсюджене на практиці. Стаття розкриває особливості зловживання правом під час виборчого процесу, аналізує приклади ...
Afanasyeva, Maryana V.   +2 more
core  

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

open access: yesAdvanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang   +11 more
wiley   +1 more source

Localizing Child Protection: Does the Local Council for the Protection of Children Matter? [PDF]

open access: yes
Child protection pertains to “preventing and responding to violence, exploitation, and abuse against children.” More specifically, it encompasses all processes, policies, programs, interventions, and measures that aim to prevent and respond to violence ...
Cuenca, Janet S.
core  

Report on the Workshop on Refugee and Asylum Policy in Practice in Europe and North America [PDF]

open access: yes, 2000
Western nations have struggled to accomplish the dual goals of refugee and asylum policies: (1) identifying and protecting Convention refugees as well as those fleeing civil conflict; and (2) controlling for abuse.
Hansen, Randall   +3 more
core   +1 more source

Stemming the Flow of Corporate Human Rights Abuses: Incorporating the Ruggie Report in the Common Law Doctrine of Foreign Judgment Enforcement

open access: yes, 2013
The eminent case of Aguinda v Chevron Corporation, currently in its twentieth year of litigation, represents a growing phenomenon in international commercial litigation between multinational corporations and victims of human rights abuse from developing ...
Carr, Erin Matariki
core   +2 more sources

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