Results 141 to 150 of about 936,114 (310)
Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression
Advanced Science, EarlyView.Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang +11 more
wiley +1 more source
Balancing recognition and disrespect: recovery as the process of identity formation: a New Zealand study of how services shape recovery from sexual abuse [PDF]
, 2007 This study explored how the recovery of victims of sexual abuse is shaped by services available. Using the philosophical underpinnings of critical theory within the framework of Honneth's recognition theory this study provides an understanding of ...
Frerichs, Gudrun
core
Advanced Science, EarlyView.Utilizing molecular engineering for network design, three pesticide‐loaded organogels (PLOs) carriers exhibiting varying degrees of flexibility were prepared. The mechanical properties of these carriers, tunable via their network molecular structures, enhance their structural adaptability and retention stability at biological interfaces, thereby ...
Yue Wang +6 more
wiley +1 more source
Scientific notes of Taurida National V.I. Vernadsky University. Series: Juridical Sciences, 2020 T.I. Brovchenko, V.O. Myrgorod
openaire +1 more source
Herald of the Association of Criminal Law of Ukraine, 2016 The article is devoted to the crime under Art. 167 of the Criminal Code, which is the use of guardianship or guardianship for personal gain to the detriment of the ward.
openaire +1 more source
1984 Is Still Fiction: Electronic Monitoring in the Workplace and U.S. Privacy Law [PDF]
, 2004 Electronic monitoring in the workplace has been the subject of relentless public criticism. Privacy advocates argue that technological advancements have given overbearing employers powerful tools to abuse employee dignity in the name of productivity and ...
Fazekas, Christopher Pearson
core +1 more source
Advanced Science, EarlyView.Mitochondria‐targeted silver single‐atom carbon dot (T‐AgSA‐CDs) nanozymes enable dual SOD/GPx‐like ROS scavenging, real‐time imaging, and therapeutic effects for acute kidney injury (AKI). Atomically dispersed Ag sites synergize with carbon dots to restore renal redox hemostasis, protect mitochondrial function, mitigate inflammation, facilitate post ...
Tianle Tang +10 more
wiley +1 more source
Disrupting the new orthodoxy: Emergency intervention and Indigenous social policy [PDF]
, 2009 This article develops a critical analysis of the ideological framework that informed the Australian Federal government’s 2007 intervention into Northern Territory Indigenous communities (ostensibly to address the problem of child sexual abuse). Continued
Hil, Richard, Thompson, Lester
core +1 more source
Advanced Science, EarlyView.This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao +8 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen +12 more
wiley +1 more source