Results 21 to 30 of about 195,584 (269)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A simplified space vector pulse width modulation method for a three‐level four‐leg inverter considering the neutral point potential balance

IET Power Electronics, 2023
This paper presents a simple three‐dimensional space vector modulation method in ghγ coordinates for a three‐level four‐leg neutral‐point‐clamped inverter.
Zhi Zhang, Haohui Chen, Yiyun Li, Sizhe Chen, Chang Liu, Zhaoyun Zhang   +5 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A source-load collaborative stochastic optimization method considering the electricity price uncertainty and industrial load peak regulation compensation benefit

International Journal of Electrical Power & Energy Systems
Energy-intensive industrial load offers substantial capacity and rapid adjustment capabilities, which can be effectively coordinated with deep peak regulation (DPR) methods of thermal power to optimize the peak regulation state of the system.
Xiaoyu Yue, Lijun Fu, Siyang Liao, Jian Xu, Deping Ke, Huiji Wang, Shuaishuai Feng, Jiaquan Yang, Xuehao He   +8 more
doaj   +1 more source

Design Approach of Grid Coupled Solar Inverter

MATEC Web of Conferences, 2018
In novel times, more demands are gained by grid connected solar inverters along with the upgrading of the solar energy generation. In grid connected solar power generation, if there is increase in placing more number of solar inverters it may result in ...
Babu Bandla Pavan, Indragandhi V., RajaSingh R., Kannan Ramani   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Neural network‐based integrated reactive power optimization study for power grids containing large‐scale wind power

IET Generation, Transmission & Distribution
The high uncertainty of wind power output greatly affects the rapid reactive power optimization of power systems. This paper proposes a neural network‐based comprehensive reactive power optimization method for large‐scale wind power grids, effectively ...
Jie Zhao, Chenhao Wang, Biao Zhao, Xiao Du, Huaixun Zhang, Lei Shang   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Fault Transient Analysis and Protection Performance Evaluation within a Large-scale PV Power Plant

MATEC Web of Conferences, 2016
In this paper, a short-circuit test within a large-scale PV power plant with a total capacity of 850MWp is discussed. The fault currents supplied by the PV generation units are presented and analysed.
Wen Jinghua, Luo Meiling, Gu Chenjie, Wei Hongsheng, Liu Bohan   +4 more
doaj   +1 more source