Results 71 to 80 of about 7,686,595 (291)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Challenges of university academic adjustment: a case study of East Asian international postgraduate students at one British university [PDF]

This is a study of international East Asian (Chinese, Taiwanese, Japanese, Thai and Korean) postgraduate students' experience of adjustment (n=40) at a university in the UK in the year 2004/5.
Wu, Wenli
core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

'Learning matters' - adjusting the media mix for academic advantage

Research in Learning Technology, 1999
Current trends in higher education are towards a greater emphasis on resource-based learning, often in a 'distance learning' or 'supported self-study' mode. Traditionally this is how Open University (OU) courses are transacted. Within the OU the typical model is for courses to go through a 'production' phase followed by a 'delivery' phase.
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Development of a causal model of academic adjustment based on emotional self-regulation and orientation of tendency dominance and the mediating role of students\' academic flourishing

مجله علوم روانشناختی, 2022
Background: Academic Adjustment refers to the ability to adapt to new information, experiences, and learning environments. Among the important features that can affect academic adjustment is the ability of emotional self-regulation and orientation of ...
Soleiman Ashkoti, Bahman Kord, Hoshang Jadidi   +2 more
doaj  

Parent Support and Peer Influence as Predictors of Academic Adjustment of Student with Visual Impairment [PDF]

Multidisciplinarni Pristupi u Edukaciji i Rehabilitaciji
This paper examined parental support and peer influence as predictor of academic adjustment of students with visual impairment in Oyo State with the purpose of identifying the relationship that exist among parental support, peer influence and academic ...
Olamide Akolawole, Sunday Abodunrin, Ibiyekaribo Wadike, Isaac Ajibade   +3 more
doaj   +1 more source

Academic Adjustment Questionnaire for the University Students

Procedia - Social and Behavioral Sciences, 2014
AbstractThe aim of this study is to develop a new psychometric instrument to explore adjustment to university requirements. The participants were 517 first year students from humanities field of Transilvania University of Brasov. Academic Adjustment Questionnaire (AAQ) is an extension of our School Inadaptation Questionnaire (SIQ) at the university ...
Clinciu, Aurel Ion, Cazan, Ana-Maria
openaire   +1 more source