Results 141 to 150 of about 1,117,148 (343)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Single‐Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein‐Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing of lung samples and flow cytometry of peripheral blood, we identified a novel T cell subset with high metallothionein (MT) expression. These MT‐high T cells suppress CD8+ T cell cytotoxicity and are progressively depleted from healthy controls to chronic obstructive pulmonary disease (COPD) patients, positioning them as
Zengqing Liu, Xiaoxia Ren, Mi Mu, Huanyu Long, Jialu Lv, Zhihong Feng, Jie Liu, Jiajia Wang, Hui Deng, Fanyu Shi, Muzhi Zhang, Ruoyang Zhang, Yang Liu, Mengyu Xu, Yang Fan, Zengtao Wang, Zhe Lv, Yan Chen, Chris J. Corrigan, Ying Sun, Yahong Chen, Chen Chen, Ye Cui, Wei Wang   +23 more
wiley   +1 more source

Visual representation of knowledge in the field of Library and Information Science of IRAN

Iranian Journal of Information Processing & Management, 2015
Purpose: The present research has been done to visual representation of knowledge and determination vacuum and density points of scientific trends of faculty members of state universities of IRAN in Library & Information Science field. Method: Curriculum
Afsoon Sabetpour, Gholamreza Fadaie, Nader Naghshineh, Vafa Ghobadpour   +3 more
doaj  

Leading the Way: Open Access Initiatives at Koç University Library

027.7
This paper provides information about Koç University Library’s key role in advancing open access principles within the university and its influential activities on the accessibility of research outputs.
Çiğdem Yıldırım
doaj   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Segments of the digital transformation of academic and research libraries: user experience at the centre

Bosniaca
Purpose: The aim of this paper is to broaden the theoretical understanding of the impact that digital transformation processes have on academic libraries and to investigate the characteristics of their digital maturity so that guidelines can be ...
Anita Katulić
doaj   +1 more source

Because research data matters : a case at the Loughborough University Library [PDF]

, 2012
Research data management is increasingly gaining importance in academic libraries, and there is a growing body of literature dedicated to this area of interest.
Melnarowicz, Ewelina
core  

Divergent Responses of Bacterial Communities to Permafrost Degradation and Their Associations With Carbon Across Vertical Profiles

Advanced Science, EarlyView.
Bacterial α‐diversity decreases, but stochasticity and community stability increase across the 15 m‐depth vertical profiles and along the degraded gradient within the active layer. The abundance and interaction of core taxa mainly control community stability in the active and permafrost layers, respectively.
Shengyun Chen, Yuzheng Gu, Ali Bahadur, Enyan Liu, Tonghua Wu, Xiaofan Zhu, Yuanqiang Zou, Hewei Liang, Peijie Wei, Linwei Wu, Qingbai Wu, Peizhi Yang, Hongyan Yu, Yunfeng Yang   +13 more
wiley   +1 more source

Academic Library and Research Data management Roles: The Case of Norwegian Libraries

, 2015
Joint Master Degree in Digital Library Learning (DILL)
openaire   +1 more source

Academic Library Leadership Issues and Challenges: An Informational Interview with Peter Sidorko, Librarian of the University of Hong Kong [PDF]

, 2016
Founded in 1911 during the British Colonial era, with the aim of competing with the other Great Powers opening universities in Mainland China, the University of Hong Kong (HKU) is the oldest tertiary institution in Hong Kong.
Chiu, KWD, Lo, P, Rogers, H
core