Results 191 to 200 of about 1,117,148 (343)

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

A qualitative study on expert perspective for implementing and utilizing non-communicable diseases research findings. [PDF]

Sci Rep
Zareivenovel M, Nemati-Anaraki L, Asadzandi S, Rasoulian B.   +3 more
europepmc   +1 more source

Exploring the academic libraries' readiness for research data management: cases from Hungary and Estonia

, 2015
The aim of this thesis was to examine the academic libraries readiness for research data management in countries where this issue is only getting recognised. Therefore, eight academic libraries from Estonia and Hungary has been contacted and asked to participate in this study.
openaire   +1 more source

Early Radial Extracorporeal Shockwave Stimulation on Proximal Tibial Circular Osteotomy Site Enhanced Heterotopic Skin Wound Healing via Small Extracellular Vesicles

Advanced Science, EarlyView.
A schematic diagram of the mechanism where small extracellular vesicles mediate the enhancement of heterotopic wound healing by radial extracorporeal shockwave stimulation at a proximal tibial osteotomy site. ABSTRACT Wound healing represents a complex biological process necessitating innovative therapeutic approaches, particularly for chronic wounds ...
Xiaoping Xie, Songqi Bi, Bang Su, Rongqi Zhou, Xudong Li, Zhixing Yan, Xiaoyang Zhou, Fanxu Wang, Tiecheng Yu   +8 more
wiley   +1 more source

Attitudes and opinions of medical practitioners, librarians, and LIS academics towards health science library services to support evidence-based medical practice in South Africa. [PDF]

PLoS One
Bala S, Underwood PG, Moyane SP.
europepmc   +1 more source

Conceptualizing Data Curation Activities Within Two Academic Libraries Senior Research Data Management Consultant Research Data Manager Graduate Research Policy Coordinator Digital Repository Content Analyst Digital Initiatives Librarian Digital Repository Content Analyst Research Data & Infrastructure Librarian Senior Research Data Management Consultant Data Services and Sociology Librarian

A growing focus on sharing research data that meet certain standards, such as the FAIR guiding principles, has resulted in libraries increasingly developing and scaling up support for research data. As libraries consider what new data curation services they would like to provide as part of their repository programs, there are various questions that ...
Sophia Lafferty-Hess, Julie Rudder, Moira Downey, Susan Ivey, Jen Darragh   +4 more
openaire   +1 more source

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

Internal factors related to self-management among type 2 diabetes patients during the COVID-19 pandemic as humanitarian emergencies: a scoping review protocol. [PDF]

Syst Rev
Yamada R, Kondo S, Xu K, Okazaki S.
europepmc   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Weight-loss effects of macronutrient-based diets modified by genetic variants: a protocol for systematic review of randomised controlled trials. [PDF]

BMJ Open
Subardjo YP, Khairunnissa NM, Kusuma RJ, Huriyati E, Susetyowati S.   +4 more
europepmc   +1 more source