Results 201 to 210 of about 1,117,148 (343)

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

The Longevity of Mobile Apps for Cancer Recovery: Scoping Review. [PDF]

JMIR Cancer
Färnqvist K, Thiele L, Johnsson S, Lagergren P, Schandl A.   +4 more
europepmc   +1 more source

Colorectal Cancer Cell's Weapon: RNF32 Engages SPP1+ Macrophages to Foster Liver Metastasis, Targeted by Indole‐3‐Acetic Acid

Advanced Science, EarlyView.
Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang, Shipeng Dai, Yuchen Xie, Pengyu Chen, Yue Chai, Chongyu Wang, Xueying Huang, Xiao Dong, Junfeng Shi, Yongxiang Xia, Xiaofeng Qian, Weiwei Tang, Yichan Zhou   +12 more
wiley   +1 more source

Temporal evolution of digital health communication in Rheumatoid Arthritis: A longitudinal NLP analysis of reddit discussions (2018-2024). [PDF]

PLoS One
Patel N, Sharma R, Lingasamy P, Sundararajan V, S SL, Modhukur V.   +5 more
europepmc   +1 more source

Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes

Advanced Science, EarlyView.
Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang, Kai Hong, Yanling Tang, Lina Cui, Xiaojian Lu, Jianxing Cheng, Yangyi Fang, Qiaoling Jiang, Ziyan Zhuang, Songzhan Gao, Hui Jiang, Qiang Liu, Jingtao Guo, Zhe Zhang, Xiaoyan Wang   +14 more
wiley   +1 more source

User experience and safety of generative AI-based mental health chatbots: Scoping review protocol. [PDF]

PLoS One
Olisaeloka L, Richardson C, Vigo D.
europepmc   +1 more source

Encapsulating Textiles with Dynamic Covalent Networks for Sustainable and Efficient Oil Spill Cleanup

Advanced Science, EarlyView.
By encapsulating industrially relevant fabrics with dynamic imine networks, we show that the resulting composites exhibit exceptional oil absorbtion capability and chemical recyclability. It is poised for sustainable oil spill cleanup. ABSTRACT The development of high‐performance sorbents for oil spill remediation is highly desirable, which now calls ...
Changyi You, Ping Yu, Haiyue Wang, Qirui Huang, Wei Hong, Cai Liu, Qinchao Sun, Yan Wang, Youwei Ma, Zuming Hu   +9 more
wiley   +1 more source

Impact of the COVID-19 pandemic on university performance: a retrospective follow-up study of the University of Split, Croatia. [PDF]

J Glob Health
Hrga J, Mijatović A, Ljutić D, Marušić A.   +3 more
europepmc   +1 more source

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

Bibliometrics and Research Data Management Services: Emerging Trends in Library Support for Research

Library Trends, 2013
S. Corrall, M. Kennan, Waseem Afzal
semanticscholar   +1 more source