Results 51 to 60 of about 22,186,001 (264)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
IDB Newsletter: Vol. 8, no. 4, October 1970
, 1970 IDB Newsletter is a monthly publication of the Inter-American Development that reports on the activities of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core +1 more source
Universitets- og høyskolepedagogikk i lys av historiske og internasjonale utviklingstrekk
Uniped, 2018 Sammendrag Universitets- og høyskolepedagogikk (UH-ped) er en aktivitet som har utviklet seg voldsomt de siste tiårene. Fra å være en aktivitet forbeholdt noen få land og institusjoner, er UH-ped blitt en etablert praksis i mange land ...
Bjørn Stensaker
doaj +1 more source
A blended learning framework for curriculum design and professional development [PDF]
Research in Learning Technology, 2015 The need for flexibility in learning and the affordances of technology provided the impetus for the rise of blended learning (BL) globally across higher education institutions.
Negin Mirriahi, Dennis Alonzo, Bob Fox
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
2019 Partnership Report: Financing a Sustainable Future [PDF]
, 2020 In 2019, the Inter-American Development Bank (IDB Group) closed out the decade with a strong focus on partnerships as a tool for amplifying development impact and generating measurable results in Latin America and the Caribbean. Recognizing the spirit of
Inter-American Development Bank
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
IDB Newsletter: Vol. 6, no. 1, January 1968
, 1968 IDB Newsletter is a monthly publication of the Inter-American Development that reports on the activities of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
IDB Newsletter: Vol. 6, no. 3, July 1968
, 1968 IDB Newsletter is a monthly publication of the Inter-American Development that reports on the activities of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core +1 more source